67093-27-0Relevant academic research and scientific papers
Dendritic poly(benzyl ether)-b-poly(N-vinylcaprolactam) block copolymers: Self-organization in aqueous media, thermoresponsiveness and biocompatibility
Tang, Gang,Hu, Minqi,He, Fuxi,You, Dan,Qian, Yangyang,Bi, Yunmei
, p. 300 - 308 (2017/12/26)
Four generations of new amphiphilic thermoresponsive linear-dendritic block copolymers (LDBCs) with a linear poly(N-vinylcaprolactam) (PNVCL) block and a dendritic poly(benzyl ether) block are synthesized by atom transfer radical polymerization (ATRP) of N-vinylcaprolactam (NVCL) using dendritic poly(benzyl ether) chlorides as initiators. The copolymers have been characterized by 1H NMR, FTIR, and GPC showing controlled molecular weight and narrow molecular weight distribution (PDI ≤ 1.25). Their self-organization in aqueous media and thermoresponsive property are highly dependent on the generation of dendritic poly(benzyl ether) block. It is observed for the LDBCs that the self-assembled morphology changes from irregularly spherical micelles, vesicles, rod-like large compound vesicles (LCVs), to the coexistence of spherical micelles and rod-like LCVs, as the generation of the dendritic poly(benzyl ether) increases. The results of a cytotoxicity study using an MTT assay method with L929 cells show that the LDBCs are biocompatible.
Synthesis of Curvulone B Using the 2-Chlorobenzyl Protecting Group
Bates, Roderick W.,Wang, Kongchen,Zhou, Guanying,Kang, Dave Zhihong
supporting information, p. 751 - 754 (2015/03/30)
A total synthesis of curvulone B has been completed using a Friedel-Crafts reaction and a highly cis-selective intramolecular oxa-Michael addition. The 2-chlorobenzyl protecting group was employed and found to have much greater Lewis acid stability compared to the simple benzyl group.
Visual detection of fluoride ions
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Page/Page column 25-26, (2015/12/18)
Dendrimer-hydrazides are coupled to polycyclic aromatic hydrocarbons for use in the visual detection of the presence of low levels of fluoride in a sample. The dendrimers can have a phenyl core, a first generation of aralkyl ethers, and an optional second generation of aralkyl ethers. The compounds form gels with solvents. In the presence of fluoride ion, the gels undergo color changes and/or gel to liquid phase change.
New derivatives of 3,4-dihydroisoquinoline-3-carboxylic acid with free-radical scavenging, d-amino acid oxidase, acetylcholinesterase and butyrylcholinesterase inhibitory activity
Solecka, Jolanta,Guspiel, Adam,Postek, Magdalena,Ziemska, Joanna,Kawcki, Robert,Lczycka, Katarzyna,Osior, Agnieszka,Pietrzak, Bartlomiej,Pypowski, Krzysztof,Wyrzykowska, Agata
, p. 15866 - 15890 (2015/01/08)
A series of 3,4-dihydroisoquinoline-3-carboxylic acid derivatives were synthesised and tested for their free-radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl radical (DPPH?), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical (ABTS?+), superoxide anion radical (O2-) and nitric oxide radical (?NO) assays. We also studied D-amino acid oxidase (DAAO), acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activity. Almost each of newly synthesised compounds exhibited radical scavenging capabilities. Moreover, several compounds showed moderate inhibitory activities against DAAO, AChE and BuChE. Compounds with significant free-radical scavenging activity may be potential candidates for therapeutics used in oxidative-stress-related diseases.
Supramolecular design for two-component hydrogels with intrinsic emission in the visible region
Rajamalli,Atta, Supriya,Maity, Sandeepan,Prasad, Edamana
supporting information, p. 1744 - 1746 (2013/03/14)
We report, for the first time, an in situ formation of two-component hydrogels from pyridine derivatives of poly(aryl ether) dendrons and tartaric acid. The two-component system (dendron + acid) undergoes J-type aggregation, leading to fibrillar type self-assembly in THF-water mixture along with blue (470 nm) and green (500 nm) intrinsic emissions. The Royal Society of Chemistry 2013.
Luminescent micro and nanogel formation from AB3 type poly(aryl ether) dendron derivatives without conventional multi-interactive gelation motifs
Rajamalli,Prasad, Edamana
supporting information; experimental part, p. 1541 - 1548 (2011/09/20)
We report the synthesis, gelation and photophysical properties of luminescent AB3 type poly(aryl ether) dendron derivatives in the absence of conventional multi-interactive gelation motifs. The gelation process is controlled through employing partial polar solvent milieu, which significantly enhances the propensity of π-π interaction between the aryl units present in the system. The self-assembly leads to unprecedented gelation through entrapping solvent molecules in the fibrillar arrangement of poly(aryl ether) units. The strategy was further utilized to prepare an excimer based photoluminescent gel through incorporating anthracene units in the dendrons. The close proximity between the anthracene units in the gel renders the formation of anthracene excimers at room temperature, resulting in the emission of bright green light from the gel, upon UV excitation. The study suggests that the size and packing of the self-assembled fibre can be controlled by the generation and functional groups present in the dendron. Furthermore, the strategy envisages an easy approach to generate fluorescent Low Molecular-mass Organic Gelator (LMOG) through incorporating poly cyclic aromatic hydrocarbon units to the poly(aryl ether) dendrons, since the self-assembly is largely guided by π-π interactions. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Low molecular weight fluorescent organogel for fluoride ion detection
Rajamalli,Prasad, Edamana
supporting information; experimental part, p. 3714 - 3717 (2011/09/12)
The design, synthesis, and the photophysical properties of a Low Molecular Weight Gel (LMWG) based on AB3 and AB2 type poly(aryl ether) dendrons with an anthracene chromophore attached through an acylhydrazone linkage are described. The gel is utilized for an efficient 'naked eye' detection of fluoride ions (as low as 0.1 equiv with respect to the gelator concentration), through a reversible gel-sol transition, which is associated with a color change from deep yellow to bright red.
Synthesis of dendritic phenol ether derivatives with a naphthalene core
Xiang, Zhonghua,Cao, Derong
, p. 1318 - 1324 (2008/09/19)
A series of dendritic phenol ether derivatives with a naphthalene core were synthesized by the Williamson reaction as a coupling reaction between 1-hydroxymethylnaphthalene and polyether-based dendritic fragments in the presence of phase-transfer catalyst and alkali. The modified method for chlorination of dendritic benzyl alcohol was also developed using PPh3 and CCl4 as reagents and CH2Cl2/CCl4 as solvent. Copyright Taylor & Francis Group, LLC.
Redox active, hybrid dendrimers containing Frechet- and Newkome-type blocks
Wang, Wei,Sun, Hao,Kaifer, Angel E.
, p. 2657 - 2660 (2008/02/08)
Equation Presented A new series of dendrimers was prepared by covalently attaching a Newkome dendron, a Freenet dendron, and a redox active, aminoferrocene group to a central triazine core. Growth of the Newkome dendron has a more pronounced effect on the
Total synthesis of (±)-quadrangularin A
Li, Wenling,Li, Hao,Li, Ying,Hou, Zijie
, p. 7609 - 7611 (2008/02/12)
The key to successful coupling in the synthesis of (±)- quadrangularin A (1) was the introduction of tert-butyl groups in the precursor to block two reactive positions. Thus, the oxidative coupling of 3,5-di-(tert-butyl) resveratrol was carried out regioselectively in an efficient total synthesis of the natural product. (Chemical Equation Presented)
