33617-49-1

Basic information

• Product Name: diethyl <3,5-bis(benzyloxy)benzyl>phosphonate
• Synonyms: diethyl <3,5-bis(benzyloxy)benzyl>phosphonate
• CAS NO: 33617-49-1
• Molecular Weight: 440.476
• Mol File: 33617-49-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: diethyl <3,5-bis(benzyloxy)benzyl>phosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl <3,5-bis(benzyloxy)benzyl>phosphonate(33617-49-1)
• EPA Substance Registry System: diethyl <3,5-bis(benzyloxy)benzyl>phosphonate(33617-49-1)

Safety Data

• Hazardous Substances Data: 33617-49-1(Hazardous Substances Data)

Upstream product

• 26153-38-8 3,5-dihydroxybenzaldehyde 
• 14615-72-6 3,5-dibenzyloxybenzaldehyde 
• 122-52-1 triethyl phosphite 
• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 58605-10-0 methyl 3,5-bis(benzyloxy)benzoate 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 67093-27-0 3,5-dibenzyloxybenzyl chloride 
• 24131-32-6 3,5-bis(benzyloxy)benzyl bromide 
• 100-44-7 benzyl chloride 
• 29654-55-5 5-(hydroxymethyl)benzene-1,3-diol 
• 78-40-0 triethyl phosphate 
• 100-39-0 benzyl bromide 
• 50513-72-9 (3,5-di-benzyloxy)benzoic acid benzyl ester 
• 99-10-5 3,5-Dihydroxybenzoic acid 

Downstream Products

• 150258-78-9 (E)-1-<3,4-bis(benzyloxy)phenyl>-2-<3,5-bis(benzyloxy)phenyl>ethene 
• 133156-35-1 (E)-1-<3,5-bis(benzyloxy)phenyl>-2-phenylethene 
• 33617-50-4 3.5-Dihydroxy-benzylphosphonsaeurediaethylester 
• 716361-87-4 (E)-1-[3'-(4''-carboxybenzamido)-4'-benzyloxy]phenyl-2-(3''',5'''-dibenzyloxy)phenylethene 
• 716361-86-3 (E)-1-[3'-(4''-t-butylbenzoyl)benzamido-4'-benzyloxy]phenyl-2-(3''',5'''-dibenzyloxy)phenylethene 
• 10083-24-6 trans-piceatannol 
• 33626-09-4 (E)-3,3',5,5'-tetrahydroxystilbene 
• 73436-03-0 2-geranyl-5-(2-phenylethyl)resorcin 
• 14531-52-3 dihydropinosylvin 
• 70610-11-6 3,5-dihydroxy-4-(3-methyl-2-butenyl)-bibenzyl 
• 133156-36-2 1,3-Bis(methoxymethoxy)-5-phenethylbenzol 
• 133156-37-3 1,3-Bis(methoxymethoxy)-2-(3-methyl-2-butenyl)-5-phenethylbenzol 
• 133156-38-4 1,3-Bis(methoxymethoxy)-2-geranyl-5-phenethylbenzol 
• 22139-77-1 pinosylvin 

Relevant articles and documents

Design and synthesis of π-extended resveratrol analogues and in vitro antioxidant and anti-inflammatory activity evaluation

The research on resveratrol (1) has been conducted intensively over a long time due to its proven antioxidant activity and disease-fighting capabilities. Many efforts have also been made to increase these biological effects. In the present study, six new extended aromatic resveratrol analogues containing naphthalene (2) and its bioisosteres quinoline (3 and 4), isoquinoline (5) quinoxaline (6) and quinazoline (7) scaffolds were designed and synthesized using an annulation strategy. The antioxidant and anti-inflammatory activities of these compounds were investigated. All compounds showed better antioxidant activity than resveratrol in ABTS assay. As for the anti-inflammatory test, 5 and 7 exhibited better activity than resveratrol. It is worth noting that nitrogen substitution on the extended aromatic resveratrol analogues has a significant impact on cell viability. Taking the antioxidant activities and NO inhibition activities into consideration, we conclude that isoquinoline analogue 5 may qualify for the further investigation of antioxidant and anti-inflammatory therapy. Furthermore, our study results suggest that in order to improve the biological activity of polyphenolic compounds, extended aromaticity and nitrogen substitution strategy could be a viable method for the design of future drug candidates.

Dimerization of piceatannol by Momordica charantia peroxidase and α-glucosidase inhibitory activity of the biotransformation products

Stilbenes, especially those oligomers, have great potential to be antihyperglycemic agents. In this study, eight stilbene dimers, including five new ones, were obtained by biotransformation of piceatannol using Momordica charantia peroxidase (MCP) for the first time. Their structures were established on the basis of spectroscopic evidences. These piceatannol dimers displayed potential α-glucosidase inhibitory activities, and trans double bond, tetrahydrofuran ring, and free adjacent phenolic dihydroxyls were found to be important for their activities. Enzymatic biotransformation of stilbenes by M. charantia peroxidase (MCP) was showed to be a prominent way to produce oligomeric stilbenes for antihyperglycemic development.

Efficient total synthesis of piceatannol via (e)-selective wittig-horner reaction

Efficient and practical total synthesis of piceatannol via (E)-selective Wittig-Horner reaction is demonstrated with six steps in overall 40% yield from a commercially available, cheap starting material, 3,5-dihydroxybenzoic acid. Wittig-Horner reaction o