13321-76-1Relevant articles and documents
Method for photocatalytic synthesis of polybrominated phenol compound in water phase
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Paragraph 0012; 0025, (2019/08/30)
The invention discloses a method for photocatalytic synthesis of a polybrominated phenol compound in a water phase, comprising the following steps: adding a catalytic amount of a radical initiator, aphenol derivative and low-toxic and cheap bromide salt and water into a reaction vessel, reacting at room temperature at 5 W power in a photocatalytic reactor for a certain period, extracting with ethyl acetate and then re-crystallizing to obtain a polybrominated phenol compound. The above radical initiator is eosin, azobisisobutanol, sodium persulfate, ammonium persulfate or potassium persulfate.The free radical initiator and the bromine salt are cheap and easily available, and the method is an ideal synthesis method of the polybrominated phenol compound. According to the method, low-toxicity bromine salt instead of liquid bromine is used to carry out a bromination reaction, unstable and explosive hydrogen peroxide is replaced with the cheap and easily-available free radical initiator, and an emerging photocatalytic method is used. The polybrominated phenol compound can be obtained in a high yield by only using a 5W power lamp for the reaction, the reaction selectivity is high, by-products are less, and the post-treatment is simple.
Preparation of carbazole and dibenzofuran derivatives by selective bromination on aromatic rings or benzylic groups with N-bromosuccinimide
Fang, Lei,Zhang, Haun,Fang, Xubin,Gou, Shaohua,Cheng, Lin
, p. 635 - 641 (2014/06/23)
N-Bromosuccinimide (NBS), a bromine source, has been used to study the bromination of toluidine and cresols systematically to clarify the underlying mechanism and the orientation effect. It has been found that bromination of toluidine and cresols which possess electron-donating NH2/OH with NBS gives electrophilic aromatic substitution products quickly instead of the desired benzylic bromination products. In contrast, when the electronic effect of the substituted groups is reversed, only the benzylic bromination products are gained. Based on this methodology, several potential AChE inhibitors, such as 2-methoxy-5-(benzylamino)methyl-dibenzofuran, 3-bromo-2-methoxy-5-methyl-9H- carbazole, 3,6-dibromo-2-methoxy-5-methyl-9H-carbazole, and 5-(bromomethyl)-2- methoxy-9H-(phenylsulfonyl)-carbazole have been synthesized.
A new mild and selective reagent for nuclear bromination
Bisarya,Rao
, p. 779 - 788 (2007/10/02)
Hexamethylene tetramine tribromide HMTAHBr3 - a new, mild and regioselective brominant is reported for bromination of aromatic hydrocarbons, substituted ethers, phenols and anilides in high yields.
SELECTIVE MONOBROMINATION OF PHENOLS
Mikhailov, V. A.,Savelova, V. A.,Rodygin, M. Yu.
, p. 1868 - 1870 (2007/10/02)
A method is proposed for the selective monobromination of the hydroxy derivatives of benzene with bis(dimethylacetamide)hydrogen tribromide in aprotic media as brominating agent.
Selective para-Bromination of Phenols via a Regenerable Polymer-bound Tetraalkylammonium Tribromide
Smith, Keith,James, D. Martin,Matthews, Ian,Bye, Martin R.
, p. 1877 - 1878 (2007/10/02)
Amberlyst-A26 resin in its tribromide form effects para-bromination of phenols with high yields and selectivity; the resin is easily recovered by filtration and can be reconverted into the tribromide form by addition of bromine.
