13330-29-5

Basic information

• Product Name: 4-BUTYL-N,N-DIMETHYLANILINE
• Synonyms: 4-BUTYL-N,N-DIMETHYLANILINE;1-(But-1-yl)-4-(dimethylamino)benzene;4-(But-1-yl)-N,N-dimethylaniline 97%
• CAS NO: 13330-29-5
• Molecular Formula: C₁₂H₁₉N
• Molecular Weight: 177.29
• Mol File: 13330-29-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 94-96/0.7mm
• Flash Point: 105.7°C
• Appearance: /
• Density: 0.917g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 4-BUTYL-N,N-DIMETHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BUTYL-N,N-DIMETHYLANILINE(13330-29-5)
• EPA Substance Registry System: 4-BUTYL-N,N-DIMETHYLANILINE(13330-29-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 13330-29-5(Hazardous Substances Data)

Usage

General Description

4-BUTYL-N,N-DIMETHYLANILINE, also known as 4-Butoxy-N,N-dimethylaniline, is an organic compound with the chemical formula C14H23N. It is a pale yellow liquid with a strong odor and is insoluble in water but soluble in organic solvents. This chemical is commonly used as a curing agent for epoxy resins and as an intermediate in the production of dyes and pigments. It is also used as a corrosion inhibitor in metalworking fluids and as a stabilizer for PVC. Additionally, 4-BUTYL-N,N-DIMETHYLANILINE has been identified as a potential environmental contaminant and is subject to various regulations and restrictions to prevent its release into the environment.

InChI:InChI=1/C12H19N/c1-4-5-6-11-7-9-12(10-8-11)13(2)3/h7-10H,4-6H2,1-3H3

Upstream product

• 861526-28-5 4-but-1-en-yl-N,N-dimethyl-aniline 
• 104-13-2 4-Butylaniline 
• 77-78-1 dimethyl sulfate 
• 586-77-6 4-bromo-N,N-dimethylaniline 
• 85167-10-8 (s)-pinanediol butylboronate 
• 26672-60-6 1-(4-(dimethylamino)phenyl)butan-1-one 
• 693-03-8 n-butyl magnesium bromide 
• 113556-00-6 p-(dimethylamino)phenyl dodecyl sulfide 
• 15499-27-1 4-n-butylchlorobenzene 
• 124-40-3 dimethyl amine 
• 542-69-8 1-iodo-butane 
• 7353-91-5 4-dimethylaminophenylmagnesium bromide 
• 109-72-8 n-butyllithium 
• 50-00-0 formaldehyd 

Downstream Products

• 104-51-8 1-butylbenzene 
• 137273-36-0 N-methyl-4-n-butylaniline 
• 14534-83-9 4-butyl-tri-N-methyl-anilinium; iodide 

Relevant articles and documents

Mildly and highly selective reductive deoxygenation of para-di- and monoalkylaminophenyl ketones by borane

Para-di- and monoalkylaminophenyl ketones were reduced selectively to para-alkyl N, N-di- and N-monoalkylanilines in good to excellent yields by borane under mild, convenient, and neutral conditions.

The Role of LiBr and ZnBr2 on the Cross-Coupling of Aryl Bromides with Bu2Zn or BuZnBr

The impact of LiBr and ZnBr2 salts on the Negishi coupling of alkylZnBr and dialkylzinc nucleophiles with both electron-rich and -poor aryl electrophiles has been examined. Focusing only on the more difficult coupling of deactivated (electron-rich) oxidative addition partners, LiBr promotes coupling with BuZnBr, but does not have such an effect with Bu2Zn. The presence of exogenous ZnBr2 shuts down the coupling of both BuZnBr and Bu2Zn, which has been shown before with alkyl electrophiles. Strikingly, the addition of LiBr to Bu2Zn reactions containing exogenous ZnBr2 now fully restores coupling to levels seen without any salt present. This suggests that there is a very important interaction between LiBr and ZnBr2. It is proposed that Lewis acid adducts are forming between ZnBr2 and the electron-rich Pd0 centre and the bromide from LiBr forms inorganic zincates that prevent the catalyst from binding to ZnBr2. This idea has been supported by catalyst design as chlorinating the backbone of the NHC ring of Pd-PEPPSI-IPent to produce Pd-PEPPSI-IPentCl catalyst now gives quantitative conversion, up from a ceiling of only 50 % with the former catalyst.

Oxygen Activated, Palladium Nanoparticle Catalyzed, Ultrafast Cross-Coupling of Organolithium Reagents

The discovery of an ultrafast cross-coupling of alkyl- and aryllithium reagents with a range of aryl bromides is presented. The essential role of molecular oxygen to form the active palladium catalyst was established; palladium nanoparticles that are highly active in cross-coupling reactions with reaction times ranging from 5 s to 5 min are thus generated in situ. High selectivities were observed for a range of heterocycles and functional groups as well as for an expanded scope of organolithium reagents. The applicability of this method was showcased by the synthesis of the [11C]-labeled PET tracer celecoxib.