137273-36-0

Upstream product

• 104-13-2 4-Butylaniline 
• 74-88-4 methyl iodide 
• 62-53-3 aniline 
• 15499-27-1 4-n-butylchlorobenzene 
• 74-89-5 methylamine 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 13330-29-5 4-n-butyl-N,N-dimethylaniline 
• 1126-78-9 N-(n-butyl)aniline 
• 222716-08-7 4-n-butylbenzyl azide 

Downstream Products

• 861793-41-1 4-butyl-N-methyl-N-nitroso-aniline 
• 55239-87-7 C₁₂H₁₆ClNO 
• 137273-37-1 Benzotriazol-1-ylmethyl-(4-butyl-phenyl)-methyl-amine 
• 137273-30-4 But-3-enyl-(4-butyl-phenyl)-methyl-amine 
• 1058161-40-2 4-(2-((4-butylphenyl)methylamino)acetyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-3'-carbonitrile 

Relevant academic research and scientific papers

Synthesis of Biaryl Phosphine Palladium(0) Precatalysts

Well-defined palladium precatalysts have become increasingly important in cross-coupling chemistry. Despite the wide choice of complexes available today, palladium(0) compounds bearing Buchwald's biaryl phosphines are still under-represented. We present here an efficient and facile synthesis of biaryl phosphine palladium(0) complexes supported by a divinyltetramethyldisiloxane (dvtms) ligand. Starting from commercially available [Pd(allyl)Cl]2, a variety of [Pd(L)(dvtms)] complexes can be accessed in high yields under mild reaction conditions. Their catalytic activity was tested in Buchwald-Hartwig couplings and found to be very good for both (hetero)aryl bromides and chlorides.

Method for selectively preparing N-monomethylamine compounds by using nitro compound as raw material

The invention discloses a method for selectively preparing N-monomethylamine compounds by using a nitro compound as a raw material. The method uses the nitro compound as the reaction raw material, formaldehyde as a methylating agent and a hydrogen gas as a reducing agent, in the presence of a supported type catalyst, a reaction is performed for 2-48 h at temperature of 10-180 DEG C in a reaction medium, and therefore the N-monomethylamine compounds are obtained, wherein the catalyst is at least one catalyst supported by palladium, platinum, ruthenium or rhodium. The method disclosed by the invention is simple, and can obtain the target product in a low-cost high-yield and high-selectivity manner; the method simplifies reaction steps, improves reaction efficiency, reduces reaction costs, and avoids separation of an intermediate product primary amine with high toxicity, easy deterioration and difficult storage; the method adopts the H2 as the reducing agent, thereby being clean, inexpensive and environmentally friendly; and the reaction conditions of the method are mild, and the catalyst is non-corrosive and easy to separate and reuse.

Method for selectively preparing N-monomethylamine compound

The invention discloses a method for selectively preparing an N-monomethylamine compound. The method takes an amine compound, formaldehyde and H2 as reaction raw materials; the raw materials react in a reaction medium in the presence of a compound catalyst at 30 DEG C-180 DEG C for 2h-48h, so as to obtain the N-monomethylamine compound; and the compound catalyst is composed of oxides of at least two of the following metal or oxides of least one of the following metal and at least one metal simple substance: aluminum, copper, nickel, cobalt and iron. According to the method for preparing the N-monomethylamine compound, the conversion ratio and the selectivity of N-monomethylamine are relatively high; the H2 is used as a reducing agent and is clean, cheap and environment-friendly; the catalyst utilized by the method is cheap, simple to prepare and high in catalysis efficiency; and the method has mild preparation and reaction conditions and the catalyst has no corrosiveness, is easy to separate and can be repeatedly used.

Base-oxidant promoted metal-free N-demethylation of arylamines

A metal-free oxidative N-demethylation of arylamines with triethylamine as a base and tert-butyl hydroperoxide (TBHP) as oxidant is reported in this paper. The reaction is general, practical, inexpensive, non-toxic, and the method followed is environmentally benign, with moderate to good yields. [Figure not available: see fulltext.]

Method For Preparing Methylated Amines

The present invention relates to a method for preparing methylated amines using carbon dioxide and to the use of the method for manufacturing vitamins, pharmaceutical products, glues, acrylic fibres and synthetic leathers, pesticides and fertilizers. The invention also relates to a method for manufacturing vitamins, pharmaceutical products, glues, acrylic fibres, synthetic leathers, pesticides and fertilizers, including a step of preparing methylated amines by the method according to the invention. The present invention also relates to a method for preparing marked methylated amines and to the uses thereof.

Catalytic methylation of aromatic amines with formic acid as the unique carbon and hydrogen source

A novel methodology is presented for the direct methylation of amines, using formic acid as a unique source of carbon and hydrogen. Based on ruthenium(II) catalysts, the formation of the N - CH3group proceeds via an efficient formylation/transfer hydrogenation pathway.

CO2 as a C1-building block for the catalytic methylation of amines

A novel catalytic reaction has been designed to utilize, for the first time, CO2 as a C1 feedstock in the synthesis of N-methylamines. Simple zinc catalysts, based on commercially available zinc salts and ligands, prove highly efficient in promoting both a 6 electron reduction of carbon dioxide and the formation of a C-N bond, using hydrosilanes and amines.

A multiligand based Pd catalyst for C-N cross-coupling reactions

An alternative approach to catalyst development, which led to a Pd catalyst based on two biarylphosphine ligands for C-N cross-coupling reactions, is reported. By effectively being able to take the form of multiple catalysts this system manifests the best properties that catalysts based on either of the two ligands exhibit separately and displays the highest reactivity and substrate scope of any system that has been reported to date for these reactions.

A highly active catalyst for Pd-catalyzed amination reactions: Cross-coupling reactions using aryl mesylates and the highly selective monoarylation of primary amines using aryl chlorides

A catalyst system based on a new biarylmonophosphine ligand (BrettPhos) that shows excellent reactivity for C-N cross-coupling reactions is reported. This catalyst system enables the use of aryl mesylates as a coupling partner in C-N bond-forming reactions. Additionally, the use of BrettPhos permits the highly selective monoarylation of an array of primary aliphatic amines and anilines at low catalyst loadings and with fast reaction times, including the first monoarylation of methylamine. Lastly, oxidative addition complexes of BrettPhos are included, which provide insight into the origin of reactivity for this system. Copyright

PIPERAZINE AND PIPERIDINE MGLUR5 POTENTIATORS

Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.