1333325-41-9

Upstream product

• 627-19-0 1-Pentyne 
• 1333325-39-5 1-benzyl 3-methyl 2,6-bis(benzyloxy)-4-(2-(methoxy(methyl)amino)-2-oxoethyl)isophthalate 
• 6121-79-5 dimethyl 4-carboxy-3,5-dihydroxyhomophthalate 
• 100-39-0 benzyl bromide 

Downstream Products

• 1141365-47-0 2-propenyl (2S,3S,3'aS,4S,5'R)-4-[2-[(1,1-dimethylethyl)diphenylsilyloxy]ethyl]-3',3'a,4,5,5',6'-hexahydro-3-methyl-5'-pentyl-8'-(2-propenyloxy)-spiro[furan-2(3H),2'-[2H]pyrano[2,3,4-de][1]benzopyran]-9'-carboxylate 
• 1182098-75-4 C₃₉H₅₀O₇Si 
• 1333325-43-1 (3R)-benzyl 6,8-bis(benzyloxy)-1-oxo-3-pentylisochroman-7-carboxylate 
• 1333325-32-8 (3R)-benzyl 6,8-bis(benzyloxy)-1-hydroxy-3-pentylisochroman-7-carboxylate 
• 1347738-63-9 (S)-benzyl 6,8-Bis(benzyloxy)-1-oxo-3-pentylisochroman-7-carboxylate 
• 1333325-52-2 C₆₀H₇₀O₈Si 

Relevant academic research and scientific papers

Formal synthesis of berkelic acid: A lesson in α-alkylation chemistry

The full details of our enantioselective formal synthesis of the biologically active natural product berkelic acid are described. The insertion of the C-18 methyl group proved challenging, with three different approaches investigated to install the correc

An Enantioselective formal synthesis of berkelic acid

An enantioselective formal synthesis of berkelic acid is described. The key step involves a late-stage silyl enol ether addition to a benzannulated oxonium ion with subsequent spiroketalization leading to construction ofthe tetracyclic core. Thermodynamic