133871-69-9

Upstream product

• 2737-22-6 2,4,6-tribromo-3-hydroxybenzaldehyde 
• 74-88-4 methyl iodide 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 64-18-6 formic acid 
• 607-99-8 2,4,6-tribromoanisole 
• 1643592-72-6 (E)-ethyl 3-(2,4,6-tribromo-3-methoxyphenyl)acrylate 
• 1643592-89-5 C₃₅H₅₅Br₃N₄O₈ 
• 1643592-92-0 C₃₄H₅₃Br₃N₄O₈ 
• 1643592-97-5 C₃₇H₅₉Br₃N₄O₈ 
• 1643593-02-5 C₂₇H₄₀Br₃N₃O₆ 
• 1643593-08-1 C₂₆H₃₈Br₃N₃O₆ 
• 1643593-14-9 C₂₉H₄₄Br₃N₃O₆ 
• 1643593-19-4 C₄₀H₅₂Br₆N₄O₈ 
• 1643593-23-0 C₃₉H₅₀Br₆N₄O₈ 
• 1643593-27-4 C₄₂H₅₆Br₆N₄O₈ 
• 1643592-77-1 (E)-3-(2,4,6-tribromo-3-methoxyphenyl)acrylic acid 

Relevant academic research and scientific papers

N-dealkylative SNAr reaction using aromatic halides: Synthesis of dihydrobenzoxazine and tetrahydrobenzoxazepine derivatives

An efficient protocol for the synthesis of dihydrobenzoxazine and tetrahydrobenzoxazepine derivatives has been developed using haloarenes involving N-dealkylative SNAr reaction. The method employs a wide variety of substrates and features the f

Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues

Marine sponges of the genus Suberea produce variety of brominated tyrosine alkaloids which display diverse range of biological activities including antiproliferative, antimicrobial and antimalarial activities. In continuation of our search for biologicall

N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).

Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: Synthesis of indoles and pyrrolo[2,3-c]pyridines

Over the past few years, the use of palladium-catalyzed aromatic carbon-nitrogen bond forming reactions by the cross-coupling of aryl halides or triflates and amines has become a useful synthetic tool. Herein, we describe a copper(I) catalyst system that allows efficient synthesis of functionalized indoles and pyrrolo[2,3-c]pyridines. This method takes advantage of amino acid promoted copper coupling of amines with aryl halides, in particular, the use of the CuI/l-proline catalyst system.

Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni

Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.