2737-22-6

Basic information

• Product Name: 3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE
• Synonyms: 3-hydroxy-2,4,6-tribromo-benzaldehyd;2,4,6-TRIBROMO-3-HYDROXYBENZALDEHYDE;3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE
• CAS NO: 2737-22-6
• Molecular Formula: C₇H₃Br₃O₂
• Molecular Weight: 358.81
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 2737-22-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 120-122°C
• Boiling Point: 305.9 °C at 760 mmHg
• Flash Point: 138.8 °C
• Appearance: /
• Density: 2.423 g/cm³
• Vapor Pressure: 0.00044mmHg at 25°C
• Refractive Index: 1.711
• Solubility: soluble in Methanol
• Sensitive: Air Sensitive
• BRN: 2098037
• CAS DataBase Reference: 3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE(2737-22-6)
• EPA Substance Registry System: 3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE(2737-22-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• RTECS: CU6900000
• Hazardous Substances Data: 2737-22-6(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-2,4,6-tribromobenzaldehyde is a chemical compound that is commonly used as a flame retardant and in the production of other chemicals. It is a derivative of benzaldehyde with three bromine atoms attached to the benzene ring and a hydroxyl group in the para position. 3-HYDROXY-2,4,6-TRIBROMOBENZALDEHYDE is known for its high thermal stability and is often used in the manufacturing of various products like plastics, textiles, and electronics to reduce their flammability. However, due to its potential toxicity and environmental impact, there are ongoing efforts to find alternative and safer flame retardant materials.

InChI:InChI=1/C7H3Br3O2/c8-4-1-5(9)7(12)6(10)3(4)2-11/h1-2,12H

Upstream product

• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 100-83-4 meta-hydroxybenzaldehyde 
• 591-31-1 3-methoxy-benzaldehyde 
• 1477-63-0 Phenylephrine 
• 623-11-0 1-methyl-4-nitrosobenzene 

Relevant articles and documents

N1,N1-dimethyl-N3-(3-(trifluoromethyl) phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis

The natural product, convolutamine I (1), has anti-trypanosomal activity however it has a high molecular weight of 473 due to a presence of 3 bromine atoms. The synthesis of the natural product convolutamine I (1) together with its analogues are presented. A SAR study against Trypanosoma brucei brucei led to compounds with improved physico-chemical properties: lower molecular weight and lower log P while maintaining potency (with a slight 2-fold improvement).

Asymmetric synthesis of amathamides A and B: Novel alkaloids isolated from Amathia wilsoni

Syntheses of the amathamides A and B ((2S)-N-[(E and Z)-2(2,4-dibromo-5-methoxyphenylethenyl]-1-methyl-2-pyrrolinecarboxamides), new alkaloids isolated from the Tasmanian marine bryozoan Amathia wilsoni, were accomplished by a sequence of reactions starting from 3-hydroxybenzaldehyde.