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8-Azaguanine, also known as a triazolopyrimidine, is a purine analogue derived from 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively. It is characterized by its yellow powder appearance and exhibits antineoplastic activity, making it a promising compound for various applications in the pharmaceutical and medical industries.

134-58-7

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Basic information
1. Product Name: 8-AZAGUANINE
2. Synonyms: 5-Amino-1H-triazolo[d]pyrimidin-7-ol;5-Amino-1H-v-triazolo(d)pyrimidin-7-ol;5-Amino-7-hydroxy-1H-triazolo[d]pyrimidine;5-Amino-7-hydroxy-1H-v-triazolo(d)pyrimidine;5-d)pyrimidin-7-ol,5-amino-v-triazolo(;5-d)pyrimidin-7-one,5-amino-1,6-dihydro-7h-v-triazolo(;7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-amino-1,4-dihydro-;7H-v-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-1,6-dihydro-
3. CAS NO:134-58-7
4. Molecular Formula: C₄H₄N₆O
5. Molecular Weight: 152.11
6. EINECS: 205-148-1
7. Product Categories: Pharmaceutical Raw Materials;Pyridines, Pyrimidines, Purines and Pteredines;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids
8. Mol File: 134-58-7.mol
Chemical Properties
1. Melting Point: >300 °C(lit.)
2. Boiling Point: 274.55°C (rough estimate)
3. Flash Point: 129.1 °C
4. Appearance: /lyophilized powder
5. Density: 1.5579 (rough estimate)
6. Vapor Pressure: 0.00149mmHg at 25°C
7. Refractive Index: 2.3000 (estimate)
8. Storage Temp.: −20°C
9. Solubility: N/A
10. PKA: 6.75±0.20(Predicted)
11. Water Solubility: 1.47E+004 mg/L
12. Merck: 896
13. CAS DataBase Reference: 8-AZAGUANINE(CAS DataBase Reference)
14. NIST Chemistry Reference: 8-AZAGUANINE(134-58-7)
15. EPA Substance Registry System: 8-AZAGUANINE(134-58-7)
Safety Data
1. Hazard Codes: Xn
2. Statements: 22
3. Safety Statements: 22-24/25
4. WGK Germany: 3
5. RTECS: XZ6157000
6. F: 10-23
7. HazardClass: N/A
8. PackingGroup: N/A
9. Hazardous Substances Data: 134-58-7(Hazardous Substances Data)

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134-58-7 Usage

Uses

Used in Antineoplastic Applications:
8-Azaguanine is used as an antineoplastic agent for its ability to inhibit cancer cell growth and proliferation. It functions as a purine antimetabolite, interfering with the synthesis of nucleic acids and proteins in cancer cells, thereby exerting its antineoplastic effects.
Used in Pharmaceutical Industry:
8-Azaguanine is used as a key component in the development of novel drugs and drug delivery systems targeting various types of cancer. Its antineoplastic properties make it a valuable asset in the creation of innovative cancer treatments and therapies.
Used in Research and Development:
8-Azaguanine is utilized as a research tool in the study of cancer biology, cell metabolism, and the development of new cancer therapies. Its unique chemical properties and antineoplastic activity allow researchers to explore its potential in various experimental settings and preclinical models.

Hazard

Mitotoic poison.

Purification Methods

Dissolve it in hot M NH4OH, filter, and cool. Recrystallise it, and wash it with water, then dry it in a vacuum. [Beilstein 26 III/IV 4171.]

Check Digit Verification of cas no

The CAS Registry Mumber 134-58-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 134-58:
(5*1)+(4*3)+(3*4)+(2*5)+(1*8)=47
47 % 10 = 7
So 134-58-7 is a valid CAS Registry Number.

InChI:InChI=1/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h1H,(H3,5,6,7,8,9,11)

134-58-7 Well-known Company Product Price

Brand
(Code)Product description
CAS number
Packaging
Price
Detail

TCI America
(A0625) 8-Azaguanine >98.0%(HPLC)(T)
134-58-7
1g
1,200.00CNY
Detail

134-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	8-azaguanine

1.2 Other means of identification

Product number	-
Other names	2-Amino-6-hydroxy-8-azapurine,2-Amino-6-oxy-8-azapurine,8-AzaG

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134-58-7 SDS

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134-58-7Related news

The Crystal and Molecular Structure of 8-AZAGUANINE (cas 134-58-7) Monohydrate09/30/2019

The x-ray analysis of the crystal structure of 8-azaguanine monohydrate is reported. Bond lengths are given with standard deviations of 0.02 A. Bond angles are given with standard deviations of 1 to 2°. All the hydrogen atoms in the structure were found. The hydrogen atom in the imidazo ring is...detailed

Study of the interaction between 8-AZAGUANINE (cas 134-58-7) and bovine serum albumin using optical spectroscopy and molecular modeling methods10/01/2019

The interaction between 8-azaguanine (8-Azan) and bovine serum albumin (BSA) in Tris-HCl buffer solutions at pH 7.4 was investigated by means of fluorescence and ultraviolet-visible (UV-Vis) spectroscopy. At 298 K and 310 K, at a wavelength of excitation (λ ex) of 282 nm, the fluorescence inten...detailed

134-58-7Relevant academic research and scientific papers

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