134000-96-7

Basic information

• Product Name: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)
• Synonyms: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI);2-Chloro-5-fluoro-4-methylpyrimidine;PyriMidine, 2-chloro-5-fluoro-4-Methyl-
• CAS NO: 134000-96-7
• Molecular Formula: C₅H₄ClFN₂
• Molecular Weight: 146.5500632
• Product Categories: PYRIMIDINE;Fluorine series
• Mol File: 134000-96-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 220℃
• Flash Point: 87℃
• Appearance: /
• Density: 1.352
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -2.05±0.29(Predicted)
• CAS DataBase Reference: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)(134000-96-7)
• EPA Substance Registry System: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)(134000-96-7)

Safety Data

• Hazardous Substances Data: 134000-96-7(Hazardous Substances Data)

Usage

General Description

Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) is a chemical compound with the molecular formula C5H3ClFN2. It is a substituted pyrimidine derivative that contains chlorine, fluorine, and a methyl group. Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of organic compounds such as dyes and pigments. Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) is a versatile building block in organic synthesis and has a range of potential applications in the chemical industry.

Upstream product

• 954220-98-5 2,4-dichloro-5-fluoro-6-methyl-pyrimidine 
• 676-58-4 methylmagnesium chloride 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1595144-31-2 (R)-N-(4-cyanophenylethyl)-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide 
• 1293283-27-8 2-(5-fluoro-4-methylpyrimidin-2-yl )-5-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole 

Relevant articles and documents

Synthesis method of 2-chloro-5-fluoro-6-methylpyrimidine

The invention relates to a synthesis method of 2-chloro-5-fluoro-6-methylpyrimidine, which comprises the following steps: dissolving sodium methoxide in methanol, adding urea, stirring, dropwisely adding ethyl 2-fluoroacetoacetate, and carrying out a reflux reaction for 2-3 hours to obtain an intermediate A; mixing the intermediate A, phosphorus oxychloride and organic alkali according to a weightratio of 1: (5-10): (0.3-2) for reaction, cooling the mixture, removing redundant phosphorus oxychloride, adding water for quenching extraction, drying, and concentrating to obtain a product B; and adding ethanol, zinc powder and acetic acid into the product B, carrying out a heating reflux reaction for 10-16 hours, cooling, filtering, evaporating to remove the ethanol, extracting with an organicsolvent, evaporating to dryness to obtain a crude product, and carrying out vacuum distillation to obtain a pure product C, namely the 2-chloro-5-fluoro-6-methylpyrimidine. The method has the effectsthat the yield is increased, the time is shortened, the operation is simple, and the post-treatment process is simplified.

IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES

Compounds having the following formula (I), or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

TRPV3 Modulators

Disclosed herein are modulators of TRPV3 of formula (I) wherein X1, X2, R1, R2, Rx, and n are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.