Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)

Base Information

• Chemical Name: Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)
• CAS No.: 134000-96-7
• Molecular Formula: C5H4ClFN2
• Molecular Weight: 146.552
• Hs Code.: 2933599590
• Mol file: 134000-96-7.mol

Synonyms:Pyrimidine, 2-chloro-5-fluoro-4-methyl-;Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI);

Chemical Property of Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)

Chemical Property:

• Boiling Point: 219.492 °C at 760 mmHg
• PKA: -2.05±0.29(Predicted)
• Flash Point: 86.546 °C
• PSA: 25.78000
• Density: 1.353 g/cm³
• LogP: 1.57750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-fluoro-4-methylpyrimidine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)

There total 5 articles about Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methylmagnesium bromide (75-16-1) + 2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-chloro-5-fluoro-4-methylpyrimidine (134000-96-7)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; diethyl ether; at -78 - 25 ℃; for 1h;

DOI:10.1021/jm401731q

Reference yield: 51.0%

methylmagnesium chloride (676-58-4) + 2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-chloro-5-fluoro-4-methylpyrimidine (134000-96-7)

Guidance literature:

With iron(III) acetylacetonate; In tetrahydrofuran; at 0 ℃; for 130h;

Reference yield: 48.0%

2,4-dichloro-5-fluoropyrimidine (2927-71-1) → 2-chloro-5-fluoro-4-methylpyrimidine (134000-96-7)

Guidance literature:

With methylmagnesium bromide; iron(III)-acetylacetonate; In tetrahydrofuran; NMP (N-methylpyrrolidone); diethyl ether; at 0 ℃; for 0.5h;

upstream raw materials:

methylmagnesium bromide

2,4-dichloro-5-fluoropyrimidine

methylmagnesium chloride

2,4-dichloro-5-fluoro-6-methyl-pyrimidine

Downstream raw materials:

(R)-N-(4-cyanophenylethyl)-1-(5-fluoro-4-methylpyrimidin-2-yl)piperidine-3-carboxamide

2-(5-fluoro-4-methylpyrimidin-2-yl )-5-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}octahydropyrrolo[3,4-c]pyrrole