1340343-75-0Relevant academic research and scientific papers
A Concise Copper-Catalyzed Oxytrifluoromethylation of Allyl Alcohols
Chen, Longhui,Feng, Xintong,Guo, Minjie,Sun, Qi,Tang, Xiangyang,Wang, Guangwei,Yang, Zequn
, (2021/12/13)
An efficient oxytrifluoromethylation of 1-aryl-substituted allyl alcohols has been developed using Togni's reagent II as a trifluoromethylation reagent and copper(I) chloride as a catalyst. This reaction proceeded through a one-pot process of trifluoromet
Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH2CF3 or ICH2CHF2 Leading to β-CF3/CHF2-Substituted Ketones
Yi, Niannian,Zhang, Hao,Xu, Chonghui,Deng, Wei,Wang, Ruijia,Peng, Dongming,Zeng, Zebing,Xiang, Jiannan
supporting information, p. 1780 - 1783 (2016/05/19)
A novel copper/silver cocatalyzed oxidative coupling of vinylarenes with ICH2CF3 or ICH2CHF2 through a radical process has been developed. The transformation provides an attractive approach to β-CF3/CHF2-substituted ketones, with the advantages of easily available starting materials and operational simplicity.
Copper-catalysed ring-opening trifluoromethylation of cyclopropanols
He, Xia-Ping,Shu, Yong-Jin,Dai, Jian-Jun,Zhang, Wen-Man,Feng, Yi-Si,Xu, Hua-Jian
, p. 7159 - 7163 (2015/07/01)
A copper-catalysed ring-opening trifluoromethylation reaction of cyclopropanols has been developed. Various β-trifluoromethyl ketones are obtained in good to excellent yields under mild reaction conditions. The present method also exhibits good functional-group compatibility. The mechanism of this new ring-opening trifluoromethylation reaction was investigated by radical trapping reactions.
Oxidative 3,3,3-trifluoropropylation of arylaldehydes
Ikeda, Akari,Omote, Masaaki,Nomura, Shiho,Tanaka, Miyuu,Tarui, Atsushi,Sato, Kazuyuki,Ando, Akira
supporting information, p. 2417 - 2421 (2014/01/06)
A reaction between (E)-trimethyl(3,3,3-trifluoroprop-1-en-1-yl)silane (1) and arylaldehydes 2 was triggered by fluoride anions to afford aryl 3,3,3-trifluoropropyl ketones 3 in moderate to good yield. A mechanistic study of this reaction indicated that it occurred via an allyl alkoxide (4). A subsequent 1,3-proton shift of the benzylic proton of 4 forms 3. This reaction involves oxidative 3,3,3-trifluoropropylation of an arylaldehyde to afford 4,4,4-trifluoro-1-arylbutan-1-one.
