134040-35-0

Upstream product

• 110-86-1 pyridine 
• 509-14-8 tetranitromethane 
• 494-40-6 asarone 
• 67-64-1 acetone 
• 86119-84-8 phosphoric acid 
• 108-24-7 acetic anhydride 
• 7664-93-9 sulfuric acid 
• 79-24-3 Nitroethane 
• 4460-86-0 asaraldehyde 
• 855272-42-3 2,4,5-trimethoxy-1-(2-nitro-1-hydroxy-propyl)-benzene 
• 860567-38-0 1-acetoxy-2-nitro-1-(2,4,5-trimethoxy-phenyl)-propane 
• 64-19-7 acetic acid 

Downstream Products

• 2020-90-8 2,4,5-Trimethoxyphenylacetone 
• 1300021-22-0 C₁₀H₁₃NO₃ 
• 93675-32-2 2,4,5-trimethoxymethamphetamine 
• 1300021-20-8 (+/-)-2,4,5-trihydroxymethamphetamine hydrobromide 
• 1083-09-6 2,4,5-trimethoxyamphetamine 
• 75014-06-1 (S)-ethyl 2-amino-2-mwthyl-3-(2,4,5-trimethoxyphenyl)propanoate 
• 75014-08-3 (R)-ethyl 2-amino-2-mwthyl-3-(2,4,5-trimethoxyphenyl)propanoate 
• 75014-04-9 (RS)-ethyl 2-amino-2-methyl-3-(2,4,5-trimethoxyphenyl)propanoate 
• 72746-40-8 (S)-6-OH-α-Me-Dopa 
• 752934-50-2 (R)-6-OH-α-Me-Dopa 
• 65520-36-7 (RS)-3-(2,4,5-trihydroxyphenyl)-2-methylalanine 
• 75014-02-7 (RS)-5-methyl-5-(2,4,5-trimethoxyphenyl)hydantoin 
• 75014-03-8 (RS)-3-(2,4,5-trimethoxyphenyl)-2-methylalanine 
• 41241-36-5 1-(2,4,5-trihydroxyphenyl)-2-aminopropane 

Relevant academic research and scientific papers

Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma

Background: Cancers of the lymphatic cells (lymphomas) account for approximately 12% of malignant diseases worldwide. The nitrostyrene scaffold is identified as a lead target structure for the development of particularly effective compounds targeting Burkitt’s lymphoma (BL). Objectives: The aims of the curent study were to synthesise a panel of nitrostyrene compounds and to evaluate their activity in Burkitt’s lymphoma (BL). Methods: A panel of structurally varied compounds were designed and synthesised using Henry Knoevenagel condensation reactions. Single crystal X-Ray analysis confirmed the E configuration for six examples of these novel structures. A number of nitrostyrene-related compounds were also investigated including 1,3-bis(aryl)-2-nitropropenes together with heterocyclic scaffolds containing the nitrovinyl pharmacophore such as 3-nitro-2-phenyl-2H-chromenes. The antiproliferative activities of the compounds were evaluated using the BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant) to establish preliminary structure-activity relationships. Results: Lead compounds with optimized nitrostyrene scaffolds and 3-nitro-2-phenyl-2Hchromene structures were successfully established with typical IC50 values of 0.45 μM and 0.47 μM in MUTU-1 cells and 1.41 μM and 1.92 μM, respectively, in DG-75 cells. The mechanism of cell death was identified as apoptotic and the lead compound was found to elicit comparable apoptotic effects to Taxol in Burkitt’s lymphoma cell lines MUTU-1 and DG-75. Conclusion: This class of pharmaceutically active compounds with potential for the treatment of Burkitt’s lymphoma suggest a potential role for nitrostyrene based agents in chemotherapy.

Synthesis and neurotoxicity profile of 2,4,5-trihydroxymethamphetamine and its 6-(N-acetylcystein-S-yl) conjugate

The purpose of the present study was to determine if trihydroxymethamphetamine (THMA), a metabolite of methylenedioxymethamphetamine (MDMA, "ecstasy"), or its thioether conjugate, 6-(N-acetylcystein-S- yl)-2,4,5-trihydroxymethamphetamine (6-NAC-THMA), pla