134277-42-2Relevant articles and documents
DMSO as a C1 Source for [2 + 2 + 1] Pyrazole Ring Construction via Metal-Free Annulation with Enaminones and Hydrazines
Guo, Haijin,Tian, Lihong,Liu, Yunyun,Wan, Jie-Ping
supporting information, p. 228 - 233 (2022/01/04)
A cascade reaction between enaminones, hydrazines, and dimethyl sulfoxide (DMSO) for the synthesis of 1,4-disubstituted pyrazoles catalyzed by molecular iodine in the presence of Selectfluor has been realized. DMSO plays a dual role as the C1 source and the reaction medium. In addition, the synthesis of 1,3,4-trisubstituted pyrazoles using aldehydes as alternative C1 building blocks has also been achieved.
Method for synthesizing 4-acyl pyrazole compound from non-cyclic ketone hydrazone
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Paragraph 0076; 0077; 0078, (2017/09/26)
The invention discloses a method for synthesizing a 4-acyl pyrazole compound from non-cyclic ketone hydrazine, and belongs to the technical field of organic synthesis. The technical scheme of the invention is characterized in that the method for synthesizing the 4-acyl pyrazole compound from the non-cyclic ketone hydrazine specifically comprises the following steps: dissolving an alpha,beta-saturated ketone compound in a solvent; adding a catalyst, a ligand and an oxidizing agent in sequence; stirring for reacting at the temperature of 100 to 140 DEG C in a nitrogen atmosphere; then, adding the non-cyclic ketone hydrazine into a reaction system; continually reacting at the temperature of 100 to 140 DEG C in an air atmosphere to obtain the 4-acyl pyrazole compound. By adopting the method, the alpha,beta-saturated ketone compound and the non-cyclic ketone hydrazine are subjected to a one-pot multi-step serial reaction under the catalysis of a copper salt to obtain the 4-acyl pyrazole compound; the method has the advantages of easiness and convenience in operation, mild conditions and wide substrate application range, and the suitable for industrial production.
1,3-Dipolar Cycloaddition Reactions of Nitrile Oxides and Nitrile Imines with 2-Methoxyvinyl Phenyl Ketone
Coutouli-Argyropoulou, E.,Thessalonikeos, E.
, p. 429 - 432 (2007/10/02)
Nitrile oxides react regioselectively with 2-methoxyvinyl phenyl ketone 1 to give 4-benzoylisoxazoles 4 via elimination of methanol from the primary cycloadducts 3.After heating with an excess of nitrile oxide bis-cycloadducts 5 were also formed.Reactions