40685-20-9

Upstream product

• 67-56-1 methanol 
• 15724-86-4 E-2-chlorovinyl phenyl ketone 
• 13829-77-1 3-(trimethylsilyl)-1-phenyl-2-propyn-1-one 
• 3623-15-2 phenyl propargyl ketone 
• 41125-10-4 benzoylacetaldehyde sodium salt 
• 77-78-1 dimethyl sulfate 
• 18609-60-4 (Z)-3-hydroxy-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 
• 98-88-4 benzoyl chloride 
• 42731-39-5 (2E)-3-hydroxy-1-phenyl-2-propen-1-one sodium salt 
• 127618-32-0 2-Diazo-3-methoxy-1-phenylpropanone 
• 6919-61-5 N-methoxy-N-methylbenzamide 

Downstream Products

• 4452-12-4 1-phenyl-3-(piperidin-1-yl)prop-2-en-1-one 
• 14677-24-8 3-Morpholinoacrylophenon 
• 96421-84-0 3-(2,6-dichlorophenyl)-4-benzoylisoxazole 
• 134277-38-6 trans-3-(2,6-dichlorophenyl)-4-(3-mesityl-5-phenyl-5H-1,4,2-dioxazol-5-yl)-5-methoxy-4,5-dihydroisoxazole 
• 134277-37-5 trans-3-(2,6-dichlorophenyl)-4-<3-(2,6-dichlorophenyl)-5-phenyl-5H-1,4,2-dioxazol-5-yl>-5-methoxy-4,5-dihydroisoxazole 
• 34310-06-0 3-mesityl-4-benzoylisoxazole 
• 134277-36-4 trans-3-mesityl-4-(3-mesityl-5-phenyl-5H-1,4,2-dioxazol-5-yl)-5-methoxy-4,5-dihydroisoxazole 
• 3506-51-2 Benzoyl acetaldehyde 
• 13125-59-2 3-methoxy-1-phenylpropan-1-ol 
• 55563-72-9 3-methoxy-1-phenylpropan-1-one 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 13945-24-9 Ethyl N-(3-oxo-3-phenylprop-1-enyl)glycinate 
• 13788-90-4 3,3-dimethoxy-1-phenylpropan-1-one 
• 19134-41-9 3-(butylamino)-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Mild acetalisation of mono and dicarbonyl compounds catalysed by titanium tetrachloride. Facile synthesis of β-keto enol ethers

The use of TiCl4, as a catalyst for the acetalisation, at room temperature, of carbonyl compounds is reported. Cyclic ketones and cyclic 1,4-diketones easily afford dimethyl acetals, but cyclic 1,3-diketones give β-keto enol ethers. Additionally, aryl ketones and acyclic ketones failed to react. β-keto aldehydes can be monoprotected either as β-keto enol ethers or β-keto dimethyl acetals depending on the reaction time and catalyst amount. Some mechanistic features are accounted for.

A convenient synthesis of masked β-ketoaldehydes by the controlled addition of nucleophiles to (trimethylsilyl)ethynyl ketones

The controlled addition of nucleophiles to (trimethylsilyl)ethynyl ketones provides a facile route to β-ketoacetals, β-alkoxy-α,β-unsaturated ketones or vinylogous amides depending on the choice of reaction conditions.