13440-22-7Relevant articles and documents
Dynamic Ligand Reactivity in a Rhodium Pincer Complex
Tang, Zhou,Otten, Edwin,Reek, Joost N. H.,Van Der Vlugt, Jarl Ivar,De bruin, Bas
, p. 12683 - 12693 (2015)
Ligand cooperativity provides (transition) metal complexes with new reactivities in substrate activation and catalytic reactions, but usually the ligand acts as an internal (Bronsted) base, while the metal acts as a (Lewis) acid. We describe the synthesis and stepwise activation of a new phosphane-pyridine-amide ligand PNNH2 in combination with RhI. The ligand is susceptible to stepwise proton and hydride loss from the nitrogen arm (imine formation) and deprotonation at the pyridylphosphine arm (dearomatization), giving rise to amine complex 1, amido species 2, imine complex 3 and dearomatized compound 4. Complex 4 bears a dual-mode cooperative PNN′ ligand containing both a (nucleophilic) basic methine fragment and a reactive (electrophilic) imine moiety. The basic ligand arm enables substrate deprotonation while the imine ligand arm enables reversible "storage" of the activated (nucleophilic) form of a sulfonamide substrate at the ligand. In combination with metal-based reactivity, this allows for the mono-alkylation of o-toluenesulfonamide with iodomethane. Compounds 1, 3 and 4 are structurally characterized. We also report the first structurally characterized example of an aminal in the coordination sphere of rhodium, complex 5, [Rh(CO)(PNN′′)], formed by sequential N-H activation of sulfonamide by the dearomatized ligand PNN′ and follow-up nucleophilic attack of anionic sulfonamide onto the imine fragment.
N-Methylation of Amines with Methanol in Aqueous Solution Catalyzed by a Water-Soluble Metal-Ligand Bifunctional Dinuclear Iridium Catalyst
Han, Xingyou,Li, Feng,Liu, Peng,Meng, Chong,Tung, Nguyen Thanh
, p. 5815 - 5824 (2020/05/26)
The N-methylation of amines with methanol in aqueous solution was proposed and accomplished by using a water-soluble metal-ligand bifunctional dinuclear iridium catalyst. In the presence of [(Cp*IrCl)2(thbpym)][Cl]2 (1 mol %), a range of desirable products were obtained in high yields under environmentally benign conditions. Notably, this research exhibited the potential of transition metal-catalyzed activation of methanol as a C1 source for the construction of the C-N bond in aqueous solution.
TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE
-
Paragraph 00322, (2017/03/21)
The present invention provides compounds of Formula (I): wherein A, Y and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.
