134430-88-9

Basic information

• Product Name: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE
• Synonyms: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE;N-(4-Methylphenyl)-3-Phenylacrylamide(WX685804)
• CAS NO: 134430-88-9
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237.3
• Mol File: 134430-88-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE(134430-88-9)
• EPA Substance Registry System: N-(4-METHYLPHENYL)-3-PHENYLACRYLAMIDE(134430-88-9)

Safety Data

• Hazardous Substances Data: 134430-88-9(Hazardous Substances Data)

Upstream product

• 102-92-1 Cinnamoyl chloride 
• 133032-63-0 6-bromomethyl-1-ethyl-1,2-dihydroquinolin-2-one 
• 106-49-0 p-toluidine 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 13939-06-5 molybdenum hexacarbonyl 
• 166824-01-7 α-phenyl p-methylcinnamyl alcohol 
• 140-10-3 (E)-3-phenylacrylic acid 
• 20080-09-5 3-(4-methylphenyl)-5-phenyl-4,5-dihydroisoxazole 
• 29289-13-2 2-iodo-4-methylaniline 
• 370558-13-7 N-(2-iodo-4-methylphenyl)cinnamamide 
• 55955-83-4 syn/anti-p-Tolyl-trans-styryl-ketoxim 

Downstream Products

• 181121-98-2 (Z)-N-(4-metilfenil)-3-fenilpropenamida 
• 117727-00-1 1-(p-Tolyl)-1,2-dihydroquinolin-2-one 
• 302939-86-2 2-bromo-6-methyl-quinoline 
• 4053-34-3 6-methylquinolin-2(1H)-one 
• 111875-39-9 N-benzoylformyl-N-(p-tolyl)cinnamamide 

Relevant articles and documents

Palladium-Catalyzed Carbonylative Synthesis of α,β-Unsaturated Amides from Styrenes and Nitroarenes

A procedure on palladium-catalyzed selective aminocarbonylation of styrenes with nitroarenes for the synthesis of α,β-unsaturated amides has been developed. A range of substituted α,β-unsaturated amides were synthesized in moderate to good yields. Interestingly, nitroarenes act as both a nitrogen source and oxidant, and Mo(CO)6 acts as a solid CO source and reductant in this catalytic system.

Imidazolium-supported benzotriazole: an efficient and recoverable activating reagent for amide, ester and thioester bond formation in water

An efficient and recyclable imidazolium-supported benzotriazole reagent (Im-CH2-BtH) as a novel synthetic auxiliary has been synthesized and its utility as a carboxyl group activating reagent via the formation of stable imidazolium-supported acyl benzotriazoles was explored for the synthesis of amides, esters and thioesters in water under microwave conditions. The reagent was reused five times without any noticeable loss in activity. It is moisture insensitive and highly stable under thermal and aerobic conditions. The application of imidazolium-supported N-acetyl benzotriazole leads to synthesis of paracetamol on the gram scale under greener conditions in 93% yield.

Design, synthesis, and evaluation of caffeic acid amides as synergists to sensitize fluconazole-resistant Candida albicans to fluconazole

A series of caffeic acid amides were designed, synthesized, and their synergistic activity with fluconazole against fluconazole-resistant Candida albicans was evaluated in vitro. The title caffeic acid amides 3-30 except 26 exhibited potent activity, and the subsequent SAR study was conducted. Compound 3, 5, 21, and 34c, at a concentration of 1.0 μg/ml, decreased the MIC80 of fluconazole from 128.0 μg/ml to 1.0-0.5 μg/ml against the fluconazole-resistant C. albicans. This result suggests that the caffeic acid amides, as synergists, can sensitize drug-resistant fungi to fluconazole. The SAR study indicated that the dihydroxyl groups and the amido groups linking to phenyl or heterocyclic rings are the important pharmacophores of the caffeic acid amides.