134560-43-3

Upstream product

• 5292-21-7 Cyclohexylacetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 23860-35-7 cyclohexylacetic acid chloride 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 149108-75-8 2-cyclohexyl-1-(pyridin-2-yl)ethan-1-one 
• 1414926-65-0 2-cyclohexyl-1-(2-hydroxyphenyl)ethan-1-one 
• 1414926-66-1 methyl 4-(2-(2-cyclohexylacetyl)phenoxy)-3-nitrobenzoate 
• 1414926-67-2 4-[1-cyclohexyl-2-(2-hydroxy-phenyl)-2-oxo-ethyl]-3-nitrobenzoic acid methyl ester 
• 863578-50-1 3-cyclohexyl-2-(2-hydroxy-phenyl)-1H-indole-6-carboxylic acid methyl ester 
• 1281318-51-1 2-cyclohexyl-1-(2-methoxyphenyl)ethan-1-one 
• 103-78-6 4-cyclohexyl-butan-2-one 
• 134560-44-4 2-Cyclohexyl-1-[4-(2-Dioxolanyl)Phenyl]Ethanone 
• 149108-78-1 (R)-2-((S)-2-Cyclohexyl-1-pyridin-2-yl-ethylamino)-2-phenyl-ethanol 

Relevant academic research and scientific papers

Metal complex, electroluminescent device containing metal complex and application of metal complex

The invention provides a metal complex, an electroluminescent device containing the metal complex and application of the electroluminescent device, the metal complex has an M(La)m(Lb)n structure, the metal complex provided by the invention can more effectively finely adjust the luminescence color and adjust the luminescence peak width, so that the half-peak width is narrowed, the luminescence color is more saturated, the device efficiency is improved, and the current efficiency and the external quantum efficiency are relatively high.

Enolizable β-Fluoroenones: Synthesis and Asymmetric 1,2-Reduction

The hydrofluorination of enolizable ynones with AgF in t-BuOH/DMF is reported. The formation of furans as side products can be suppressed using 2,2′-biphenol. The corresponding β-fluoroenones were obtained with good Z-selectivity. A variety of functional groups are tolerated. β-Fluoroenones are vinylogous acid fluorides whose hydrolysis to vinylogous acids can be avoided under the reported reaction conditions. The asymmetric 1,2-reduction of β-fluoroenones to 3-fluoroallylic alcohols is possible with pinacolborane and a Ni(0) catalyst prepared from a pyrimidyloxazoline ligand.

'Wake-Up Call of A Sleeping Beauty': Straightforward Synthesis of Functionalized β-(2-Pyridyl) Ketones from 2,6-Lutidine

β-(2-Pyridyl) ketones are a unique class of heterocycles with valuable physicochemical properties and emerging relevance as pharmacophores. Herein we report a one-step process for the preparation of various substituted β-(2-pyridyl) ketones from the common starting material, 2,6-lutidine. Furthermore, we demonstrate the utility of this building block by synthesizing of a small set of antimalarial natural products.

An efficient process for the large-scale synthesis of a 2,3,6-trisubstituted indole

The efficient synthesis of a key trisubstituted indole intermediate 1 is described. The synthetic route required the use of an aryl Grignard reagent which was not commercially available, and the large-scale formation of this fragment and the thermal evalu

A Weinreb amide approach to the synthesis of trifluoromethylketones

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: From benzimidazole to indole scaffolds

Benzimidazole-based allosteric inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified to a variety of topologically related scaffolds. Replacement of the polar benzimidazole core by lipophilic indoles led to inhibitors with improved potency in the cell-based subgenomic HCV replicon system. Transposing the indole scaffold into a previously described series of benzimidazole-tryptophan amides generated the most potent inhibitors of HCV RNA replication in cell culture reported to date in this series (EC50 ～ 50 nM).

A SIMPLE AND EFFECTIVE ENANTIOMERIC SYNTHESIS OF A CHIRAL PRIMARY AMINE

Catalytic reduction of chiral 2-(2-pyridyl)-1,3-oxazolidines and 2-pyridyl imines derived from (R)-phenylglycinol and (R)-valinol afforded high diastereomeric selectivity.Upon oxidative cleavage, the S-primary amine with high ee was obtained.

Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines

This invention relates to substituted imidazopyridine dervatives having the following formula STR1 and isomers thereof; or a pharmaceutically acceptable acid addition salt thereof: wherein R1 and R2 are each independently selected fr