1346447-16-2

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 124-38-9 carbon dioxide 
• 186519-89-1 7-(benzenesulfonyl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 1355969-36-6 (4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone 
• 1355969-38-8 (4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-methanone 
• 1355969-31-1 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbonyl chloride 
• 1355970-15-8 (5-(benzyloxy)-1H-indol-2-yl)(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanone 
• 1355969-79-7 (R)-(1H-indol-2-yl)(4-(1-phenylethylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanone 
• 1355969-77-5 (4-(benzylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone 
• 1355969-74-2 (4-(4-hydroxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone 
• 1355969-72-0 (4-(2-chloro-4-(3-fluorobenzyloxy)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone 
• 1355969-70-8 (4-(4-bromo-2-fluorophenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone 
• 1355969-65-1 (4-(3-iodophenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-pyrrolo[2,3-b]pyridin-2-yl)methanone 
• 1355969-62-8 (4-(3-iodophenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(5-methoxy-1H-indol-2-yl)methanone 
• 1355969-59-3 (1H-indol-2-yl)(4-(3-iodophenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanone 
• 1355969-55-9 (4-(3-ethynylphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanone 

Relevant academic research and scientific papers

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H- pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4- (phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

Several members of the quinazoline class of known tyrosine kinase inhibitors are approved anticancer agents, often showing selectivity for receptors of the HER/ErbB-family. Combining structural elements of this class with the bisindolylmethanone-structure