The Role of Trichloroacetimidate to Enable Iridium-Catalyzed Regio- And Enantioselective Allylic Fluorination: A Combined Experimental and Computational Study

Article abstract of DOI:10.1021/jacs.9b07575

Asymmetric allylic fluorination has proven to be a robust and efficient methodology with potential applications for the development of pharmaceuticals and practical synthesis for ¹⁸F-radiolabeling. A combined computational (dispersion-corrected

Full text of DOI:10.1021/jacs.9b07575

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Article
The Role of Trichloroacetimidate To Enable Iridium-
Catalyzed Regio- and Enantioselective Allylic Fluorination:
A Combined Experimental and Computational Study
Alexandre M. Sorlin, Jason C. Mixdorf, Madeline Rotella,
Robert Martin, Osvaldo Gutierrez, and Hien M. Nguyen
J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/jacs.9b07575 • Publication Date (Web): 22 Aug 2019
Downloaded from pubs.acs.org on August 22, 2019
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ACS Paragon Plus Environment

Journal of the American Chemical Society
Page 20 of 26
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ACS Paragon Plus Environment

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Journal of the American Chemical Society
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ACS Paragon Plus Environment

Journal of the American Chemical Society
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ACS Paragon Plus Environment

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Journal of the American Chemical Society
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ACS Paragon Plus Environment

Journal of the American Chemical Society
Page 24 of 26
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ACS Paragon Plus Environment

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Journal of the American Chemical Society
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ACS Paragon Plus Environment

Journal of the American Chemical Society
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