13472-61-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-5-Iodopyridine is used as a synthetic building block for the creation of various pharmaceutical drugs and agrochemicals. Its unique structure allows it to be a key component in the development of new and effective compounds for medical and agricultural applications.
Used in Cancer Research:
2-Methoxy-5-Iodopyridine is used as a subject of study in cancer research for its potential anti-cancer properties. 2-Methoxy-5-Iodopyridine is being investigated to understand its effects on cancer cells and to explore its possible use in the development of new cancer treatments.
Safety Considerations:
As a hazardous substance, 2-Methoxy-5-Iodopyridine requires proper safety precautions during its handling, storage, and use to minimize risks to human health and the environment.

InChI:InChI=1/C12H18BNO3/c1-11(2)12(3,4)17-13(16-11)9-6-7-10(15-5)14-8-9/h6-8H,1-5H3

Upstream product

• 69045-79-0 2-choro-5-iodopyridine 
• 74-88-4 methyl iodide 
• 73290-22-9 2-bromo-5-iodo-pyridine 
• 67-56-1 methanol 
• 116195-81-4 2,5-di-iodopyridine 
• 124-41-4 sodium methylate 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 1628-89-3 2-methoxypyridine 
• 20511-12-0 2-amino-5-iodopyridine 
• 504-29-0 2-aminopyridine 

Downstream Products

• 1083329-15-0 5-(benzyloxy)-2-methoxypyridine 
• 902130-84-1 2-(6-methoxy-pyridin-3-yl)-malonic acid diethyl ester 
• 663955-53-1 3-(phenylethynyl)-6-methoxypyridine 
• 32401-35-7 (6-methoxypyridine-3-yl)(phenyl)methanol 
• 1628-89-3 2-methoxypyridine 
• 95881-82-6 6,6′-dimethoxy-3,3′-bipyridine 
• 5789-31-1 3,4-diphenyl-hexane 

Relevant academic research and scientific papers

Copper-catalyzed trifluoromethylation of alkoxypyridine derivatives

The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.

Preparation method of 2,5-dimethoxy pyridine

The invention discloses a preparation method of 2,5-dimethoxy pyridine, and belongs to the technical field of medicine synthesis. The method comprises the following steps that 1, under the existence of an alcohol solvent, a compound shown as a formula A and sodium methoxide take contact reaction to form a compound shown as a formula B; 2, under the existence of metal catalysts, the compound shownas a formula B in the first step reacts to obtain 2,5-dimethoxy pyridine; aftertreatment and purification are performed to obtain the product. The method has the advantages that the route is short; the steps are few; expensive palladium catalysts and boracic acid catalysts are not used; the equipment cost is reduced; the use of flammable and explosive lithium reagents and peroxide is avoided; thereaction conditions are mild; the aftertreatment operation is simple and convenient; the total yield and the purity are improved; the product quality can be easily controlled; the industrial amplification prospects are good.

A Magnesium-Based Diastereoselective Preparation of Pyridylic 1,3-Amino Alcohols Using the tert -Butyl Sulfinamide Auxiliary

1,3-Amino alcohols were prepared by using a two-step approach and an interesting reversal in diastereoselectivity is discussed.

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles

A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks. The reaction tolerates a variety of heterocyclic coupling partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines. The reaction proceeds under mild conditions at room temperature and precludes the need to pregenerate organometallic nucleophiles.

Noncryogenic synthesis of functionalized 2-methoxypyridines by halogen-magnesium exchange using lithium dibutyl(isopropyl)magnesate(1-) and lithium chloride

2-Methoxypyridines functionalized in the 3-, 5-, or 6-position and 2,6-dimethoxypyridines functionalized in the 3-position were prepared from the corresponding bromo or iodo analogues by using lithium dibutyl(isopropyl) magnesate(1-) and lithium chloride

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.