13472-61-2Relevant articles and documents
Copper-catalyzed trifluoromethylation of alkoxypyridine derivatives
Farkas, Emese,Gyorfi, Nandor,Kotschy, Andras,Nemet, Norbert,Novak, Zoltan,Weber, Csaba
, (2020/10/27)
The trifluoromethylation of aromatic and heteroaromatic cores has attracted considerable interest in recent years due to its pharmacological relevance. We studied the extension of a simple copper-catalyzed trifluoromethylation protocol to alkoxy-substituted iodopyridines and their benzologs. The trifluoromethylation proceeded smoothly in all cases, and the desired compounds were isolated and characterized. In the trifluoromethylation of 3-iodo-4-methoxyquinoline, we observed a concomitant O-N methyl migration, resulting in the trifluoromethylated quinolone as a product. Overall, the described procedure should facilitate the broader use of copper-catalyzed trifluoromethylation in medicinal chemistry.
A Magnesium-Based Diastereoselective Preparation of Pyridylic 1,3-Amino Alcohols Using the tert -Butyl Sulfinamide Auxiliary
Fjelbye, Kasper,Svenstrup, Niels,Püschl, Ask
, p. 3231 - 3240 (2015/10/19)
1,3-Amino alcohols were prepared by using a two-step approach and an interesting reversal in diastereoselectivity is discussed.
Noncryogenic synthesis of functionalized 2-methoxypyridines by halogen-magnesium exchange using lithium dibutyl(isopropyl)magnesate(1-) and lithium chloride
Struk, Lukasz,Sosnicki, Jacek G.
experimental part, p. 735 - 746 (2012/04/04)
2-Methoxypyridines functionalized in the 3-, 5-, or 6-position and 2,6-dimethoxypyridines functionalized in the 3-position were prepared from the corresponding bromo or iodo analogues by using lithium dibutyl(isopropyl) magnesate(1-) and lithium chloride
