2-Methoxy-5-Iodopyridine

Base Information

• Chemical Name: 2-Methoxy-5-Iodopyridine
• CAS No.: 13472-61-2
• Molecular Formula: C6H6INO
• Molecular Weight: 235.024
• Hs Code.: 29333990
• Mol file: 13472-61-2.mol

Synonyms:2-Methoxy-5-iodopyridine;5-Iodo-2-methoxypyridine;

Chemical Property of 2-Methoxy-5-Iodopyridine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 237.197 °C at 760 mmHg
• PKA: 1.38±0.10(Predicted)
• Flash Point: 97.253 °C
• PSA: 22.12000
• Density: 1.826g/cm³
• LogP: 1.69480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

5-Iodo-2-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-5-Iodopyridine

There total 11 articles about 2-Methoxy-5-Iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-methoxy-5-bromopyridine (13472-85-0,1199266-76-6) → 5-iodo-2-methoxypyridine (13472-61-2)

Guidance literature:

2-methoxy-5-bromopyridine; With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at -2 - 0 ℃; for 0.75h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0031-1289687

Reference yield: 82.7%

2,5-di-iodopyridine (116195-81-4) + sodium methylate (124-41-4) → 5-iodo-2-methoxypyridine (13472-61-2)

Guidance literature:

In methanol; at 40 ℃; for 36h;

Reference yield: 69.0%

2-bromo-5-iodo-pyridine (73290-22-9) + methanol (67-56-1) → 5-iodo-2-methoxypyridine (13472-61-2)

Guidance literature:

methanol; With sodium; In methanol;

2-bromo-5-iodo-pyridine; at 20 ℃;

DOI:10.1021/jo801501e

upstream raw materials:

2-choro-5-iodopyridine

methyl iodide

2-aminopyridine

2-amino-5-iodopyridine

Downstream raw materials:

5-(benzyloxy)-2-methoxypyridine

2-(6-methoxy-pyridin-3-yl)-malonic acid diethyl ester

3-(phenylethynyl)-6-methoxypyridine

(6-methoxypyridine-3-yl)(phenyl)methanol