1349699-55-3Relevant academic research and scientific papers
TOLL-LIKE RECEPTOR SIGNALING INHIBITORS
-
Paragraph 00287, (2019/07/20)
Di- and triaryl-substituted heteroaromatic compounds have Toll-like receptor inhibitory activity, including at TLR2, TLR4, TLR7, and/or TLR9. Compounds and compositions have applications in the treatment of diseases and conditions mediated by Toll-like receptors and related receptors, such as bacterial sepsis, autoimmune disease, lupus erythematosus, ischemia-reperfusion injury, stroke, metabolic disease, obesity-related metabolic inflammation, gout, and cancer.
Büchwald-Hartwig Reaction Applied to Synthesis of New Luminescent Liquid Crystal Triarylamines Derived from Isoxazoles
Vilela,Fernandes,Kelly,Merlo
, p. 169 - 182 (2015/07/15)
The present work describes the synthesis and characterization of novel series of triarylamines isoxazoles (TAA) addressed to the organic photovoltaic materials. Diarylisoxazoles were synthesized by sequential [3+2] 1,3-dipolar cycloaddition reaction betwe
3,5-diarylisoxazoles: A New Entry to Soft Crystal Phase
Da Rosa, Rafaela R.,Brose, Irwing S.,Vilela, Guilherme D.,Merlo, Aloir A.
, p. 158 - 168 (2015/07/15)
This work describes the synthesis and characterization of a new liquid-crystalline compounds based on isoxazoles. Classical synthetic methodologies were employed in the preparation of this compounds, and the [3+2] 1,3-dipolar cycloaddition was the key ste
Expeditious preparation of isoxazoles from Δ2-isoxazolines as advanced intermediates for functional materials
Vilela, Guilherme D.,Da Rosa, Rafaela R.,Schneider, Paulo H.,Bechtold, Ivan H.,Eccher, Juliana,Merlo, Aloir A.
experimental part, p. 6569 - 6572 (2012/01/03)
A collection of isoxazoles derivatives has been efficiently synthesized in three steps. The oximation reaction of aldehydes followed by nitrile oxide [3+2] 1,3-dipolar cycloaddition and MnO2-oxidation reaction furnished the title compounds which were purified by simple filtration on celite.
