135307-32-3Relevant academic research and scientific papers
Synthesis of 2-Amino Substituted Oxazoles from α-Amino Ketones and Isothiocyanates via Sequential Addition and I2-Mediated Desulfurative Cyclization
Chang, Junbiao,Yu, Wenquan,Zhang, Shuangshuang,Zhao, Qiongli,Zhao, Yifei
, (2020)
Oxazol-2-amines were synthesized by annulation of α-amino ketones and isothiocyanates. This sequential synthetic process involves addition of α-amino ketones to isothiocyanates and I2-promoted desulfurative cyclization omitting isolation of the less stable thiourea intermediates. It is transition metal-free and operationally simple, providing access to a variety of 2-amino substituted oxazole derivatives under mild reaction conditions. (Figure presented.).
NEW APPLICATIONS OF IMINOPHOSPHORANES. THE PREPARATION OF β-KETO CARBODIIMIDES AND THEIR REARRANGEMENT TO 2-AMINO-1,3-OXAZOLES
Froeyen, Paul
, p. 81 - 84 (2007/10/02)
β-Keto carbodiimides (3) have been synthesized by reacting 2-azido ketones (1) with triphenylphosphine in the presence of isocyanates/isothiocyanates; the former compounds (3) are readily transformed into 2-amino-1,3-oxazoles (4).Key words: Synthesis; imi
