135357-02-7Relevant articles and documents
LANTHANIDE INDUCED INTRAMOLECULAR COUPLING OF ALDEHYDES AND KETONES WITH ELECTRON-DEFICIENT OLEFINS
Enholm, Eric J.,Trivellas, Antigone
, p. 1063 - 1066 (1989)
Aldehydes or ketones with a δ,ε-olefin bearing a conjugating electron-withdrawig group undergo reductive cyclization with samarium iodide to afford five membered rings.Diastereoselectivities of >250:1 have been obtained.
Dual Activation of Unsaturated Amides with Schwartz's Reagent: A Diastereoselective Access to Cyclopentanols and N,O-Dimethylcyclopentylhydroxylamines.
Coelho, Aurélien,Souvenir Zafindrajaona, Mahasoa-Salina,Vallée, Alexis,Behr, Jean-Bernard,Vasse, Jean-Luc
supporting information, (2021/12/06)
The diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines from 4-pentenoic acid-derived Weinreb amides is described. Based on the concomitant generation of both the nucleophilic and the electrophilic poles by hydrozirconati
INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
-
, (2021/10/15)
Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.
One-pot β-alkylation of secondary alcohols with primary alcohols catalyzed by ruthenacycles
Chang, Xu,Chuan, Low Wei,Yongxin, Li,Pullarkat, Sumod A.
experimental part, p. 1450 - 1455 (2012/04/10)
A ruthenacycle-catalyzed one-pot β-alkylation of secondary alcohols with primary alcohols is described. A survey of four C-N chelate ruthenacycles synthesized via the cyclometallation reaction of phenylmethanamine, N-methylphenylmethanamine, N,N-dimethylphenylmethanamine, and naphthalen-1-ylmethanamine with [(η6-C6H 6)RuCl2]2 was undertaken. All four complexes were found to be active with the phenylmethanamine-based ruthenacycle showing the best combination of reactivity and product selectivity among the four. An expanded scope of substrates was also studied with the inclusion of unsaturated primary alcohols. The reactivity trend observed gave insights into the role of hydrogen bonding in the catalytic mechanism involving transfer hydrogenation between the substrates and the transition metal catalyst.
