135682-94-9

Upstream product

• 1879-53-4 E-1-(4-chlorophenyl)-1-propene 
• 1879-52-3 cis-4-chloro-β-methylstyrene 
• 2809-65-6 4-chloro-1-propynylbenzene 
• 873-73-4 4-n-chlorophenylacetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 13856-85-4 1-(4-chlorophenyl)-1-propanol 
• 29125-75-5 p-chloro(methylstyrene) 
• 766-90-5 cis-1-phenyl-1-propylene 

Relevant academic research and scientific papers

Asymmetric epoxidation of alkenes catalysed by chromium binaphthyl Schiff base complex supported on MCM-41

A chromium(III) binaphthyl Schiff base complex immobilised on modified MCM-41 is an effective catalyst for asymmetric epoxidation of unfunctionalised alkenes and gave significantly higher ee than the free complex.

Enhanced Turnover for the P450 119 Peroxygenase-Catalyzed Asymmetric Epoxidation of Styrenes by Random Mutagenesis

A randomized library is constructed based on pET30a-CYP119-T214V plasmid. This library of random mutants of CYP119-T214V was screened by means of the reduced CO difference spectra and epoxidation of styrene. By using directed evolution, a new CYP119 quadr

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis-β-Methylstyrenes

P450 119 peroxygenase and its site-directed mutants are discovered to catalyze the enantioselective epoxidation of methyl-substituted styrenes. Two new site-directed P450 119 mutants, namely T213Y and T213M, which were designed to improve the enantioselectivity and activity for the epoxidation of styrene and its methyl substituted derivatives, were studied. The T213M mutant is found to be the first engineered P450 peroxygenase that shows highly enantioselective epoxidation of cis-β-methylstyrenes, with up to 91 % ee. Molecular modeling studies provide insights into the different catalytic activity of the T213M mutant and the T213Y mutant in the epoxidation of cis-β-methylstyrene. The results of the calculations also contribute to a better understanding of the substrate specificity and configuration control for the regio- and stereoselective peroxygenation catalyzed by the T213M mutant.

Synthesis of enantiopure 2-amino-1-phenyl and 2-amino-2-phenyl ethanols using enantioselective enzymatic epoxidation and regio- and diastereoselective chemical aminolysis

Several enantiopure 1,2-amino alcohols have been prepared by combining a stereoselective enzymatic epoxidation of styrenes with regio- and stereoselective chemical reactions. An interesting reactivity has been noted concerning the reaction of epoxides and NH3 under microwave activation.

Asymmetric epoxidation of cis-β-methylstyrenes catalyzed by N-aryl substituted oxazolidinone-containing ketones. A beneficial substituent effect

Asymmetric epoxidation of substituted cis-β-methylstyrenes using N-aryl substituted oxazolidinone-containing ketones as catalysts shows that substituents on the phenyl group of the olefin have significant positive effects on the enantioselectivity of the