Nucleoside H-phosphonates. 15. Preparation of nucleoside H-phosphonothioate monoesters from the corresponding nucleoside H-phosphonates

Article abstract of DOI:10.1021/jo00130a025

A convenient method for the preparation of nucleoside 3'-H-phosphonothioate monoesters from suitably protected nucleoside 3'-H-phosphonates has been developed. It consists of activation of nucleoside H-phosphonates with pivaloyl chloride in the presence of a limited amount of a base followed by treatment with 1,1,1,3,3,3-hexamethyldisilathiane (HMDST).