1357159-29-5

Basic information

• Product Name: tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate
• Synonyms: tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate
• CAS NO: 1357159-29-5
• Molecular Weight: 415.535
• Mol File: 1357159-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate(1357159-29-5)
• EPA Substance Registry System: tert-butyl 1-(4-(6-amino-3-phenylpyridin-2-yl)phenyl)cyclobutylcarbamate(1357159-29-5)

Safety Data

• Hazardous Substances Data: 1357159-29-5(Hazardous Substances Data)

Upstream product

• 86847-84-9 2,2-Dimethyl-N-(6-chloro-2-pyridinyl)propanamide 
• 1357159-28-4 tert-butyl 1-(4-(6-amino-3-chloropyridin-2-yl)phenyl)cyclobutylcarbamate 
• 98-80-6 phenylboronic acid 
• 1192814-45-1 5,6-dichloropyridin-2-amine 
• 1192814-44-0 N-(5,6-dichloropyridin-2-yl)pivalamide 
• 1032528-06-5 {1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester 

Downstream Products

• 1357159-30-8 tert-butyl 1-(4-(6-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)phenyl)cyclobutylcarbamate 

Relevant articles and documents

Diverse heterocyclic scaffolds as allosteric inhibitors of AKT

Wide-ranging exploration of potential replacements for a quinoline-based inhibitor of activation of AKT kinase led to number of alternative, novel scaffolds with potentially improved potency and physicochemical properties. Examples showed predictable DMPK properties, and one such compound demonstrated pharmacodynamic knockdown of phosphorylation of AKT and downstream biomarkers in vivo and inhibition of tumor growth in a breast cancer xenograft model.