135908-05-3Relevant academic research and scientific papers
A New Enzymatic Synthesis of (R)-γ-Chloro-β-Hydroxybutyronitrile
Nakamura, Tetsuji,Nagasawa, Toru,Yu, Fujio,Watanabe, Ichiro,Yamada, Hideaki
, p. 11821 - 11826 (2007/10/02)
A new enzymatic synthesis of (R)-γ-chloro-β-hydroxybutyronitrile from epichlorohydrin or 1,3-dichloro-2-propanol using halohydrin hydrogen-halide-lyase purified from a recombinant Escherichia coli that carried the enzyme gene of Corynebacterium sp. strain N1074 was described.
β,γ-EPOXY SULFONES IN ORGANIC SYNTHESIS. PART 2: PREPARATION OF β,γ-BIFUNCIONALIZED SULFONES
Najera, Carmen,Sansano, Jose M.
, p. 5193 - 5202 (2007/10/02)
Heteronucleophiles reagents react with β,γ-epoxy sulfones 1 at the γ position in the presence of Ti(OPri)4 or magnesium halides to afford regioselectively γ-functionalized β-hydroxy sulfones 2.With soft nucleophiles such as sodium azide, triphenylphosphine, or sodium benzethiolate the reaction takes place in the absence of Lewis acids.In the case of basic reagents such as sodium methoxide or diethylamine the corresponding regioisomers, the β-functionalized γ-hydroxy sulfones 3 were exclusively obtained.The preparation of compounds 3 (R2 = H) was also carried out starting from 3-tosyl-2-propen-1-ol (4) by Michael addition of different heteronucleophiles.
Piperazine derivatives of theophylline and theobromine
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, (2008/06/13)
New compounds of formulas I and II STR1 and the pharmaceutically acceptable acid addition salts thereof, wherein M is selected from the group consisting of hydrogen, morpholino, benzylamino, di-n-lower alkylamino, n-lower alkylamino and STR2 wherein Ar is
