1363386-97-3

Basic information

• Product Name: [1-(phenylmethyl)-1H-indol-3-yl](4′-phenylpiperazin-1′-yl)methanone
• Synonyms: [1-(phenylmethyl)-1H-indol-3-yl](4′-phenylpiperazin-1′-yl)methanone
• CAS NO: 1363386-97-3
• Molecular Weight: 395.504
• Mol File: 1363386-97-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [1-(phenylmethyl)-1H-indol-3-yl](4′-phenylpiperazin-1′-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(phenylmethyl)-1H-indol-3-yl](4′-phenylpiperazin-1′-yl)methanone(1363386-97-3)
• EPA Substance Registry System: [1-(phenylmethyl)-1H-indol-3-yl](4′-phenylpiperazin-1′-yl)methanone(1363386-97-3)

Safety Data

• Hazardous Substances Data: 1363386-97-3(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 3377-71-7 N-benzylindole 
• 67-66-3 chloroform 
• 27018-76-4 1-benzylindole-3-carboxylic acid 
• 10511-51-0 1-Benzylindole-3-carboxaldehyde 
• 1363386-89-3 2-(1-benzyl-1H-indole-3-carbonyl)-1,3-dicyclohexylisourea 
• 487-89-8 Indole-3-carboxaldehyde 
• 120-72-9 indole 

Relevant articles and documents

Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group

Chloroform-mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three-component aminocarbonylation reaction proceeded via in-situ generation of phosgene from chloroform and O2 to provide indole-3-carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.