1363386-97-3Relevant academic research and scientific papers
Acylative Coupling of Amine and Indole Using Chloroform as a Carbonyl Group
Nishida, Yuika,Takeda, Norihiko,Matsuno, Kenji,Miyata, Okiko,Ueda, Masafumi
, p. 3928 - 3935 (2018/07/31)
Chloroform-mediated acylative coupling of amines with indoles has been developed. When indoles and amines in chloroform were treated with dimethylzinc in the presence of air, the three-component aminocarbonylation reaction proceeded via in-situ generation of phosgene from chloroform and O2 to provide indole-3-carboxamides in a single operation. Application to the synthesis of biologically active compounds and intramolecular acylation are also described.
Synthesis of 1-benzyl-3-[4-(aryl-1-piperazinyl) carbonyl]-1h-indoles. novel ligands with potential D4 dopaminergic activity
Pessoa-Mahana, Hernan,Ignacio Cuevas,David Pessoa-Mahana,Araya-Maturana, Ramiro,Fajardo, Iriux Almodovar,Barria, Claudio Saitz
, p. 866 - 869 (2012/05/04)
The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1- piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through a five steps sequence
