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27018-76-4

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27018-76-4 Usage

Uses

Different sources of media describe the Uses of 27018-76-4 differently. You can refer to the following data:
1. Reactant for preparation of:? ;Indoleacetic acid analogs as differentiation-inducing and antiproliferative agents for human myeloblastoma cells1? ;Indole-carboxamide derivatives as inhibitors of lipid peroxidation and superoxide anion formation2? ;Indole carboxamides as hyaluronidase inhibitors3? ;Fuconojirimycin derivatives as inhibitors of α-fucosidases4? ;Indole-2 and 3-carboxamides as selective cyclooxygenase-2 inhibitors5? ;Indole amides as antihistaminic agents6
2. Reactant for preparation of:Indoleacetic acid analogs as differentiation-inducing and antiproliferative agents for human myeloblastoma cellsIndole-carboxamide derivatives as inhibitors of lipid peroxidation and superoxide anion formationIndole carboxamides as hyaluronidase inhibitorsFuconojirimycin derivatives as inhibitors of α-fucosidasesIndole-2 and 3-carboxamides as selective cyclooxygenase-2 inhibitorsIndole amides as antihistaminic agents

Check Digit Verification of cas no

The CAS Registry Mumber 27018-76-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,0,1 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 27018-76:
(7*2)+(6*7)+(5*0)+(4*1)+(3*8)+(2*7)+(1*6)=104
104 % 10 = 4
So 27018-76-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H13NO2/c18-16(19)14-11-17(10-12-6-2-1-3-7-12)15-9-5-4-8-13(14)15/h1-9,11H,10H2,(H,18,19)/p-1

27018-76-4 Well-known Company Product Price

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  • (Code)Product description
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  • Alfa Aesar

  • (H66294)  1-Benzylindole-3-carboxylic acid, 95%   

  • 27018-76-4

  • 1g

  • 840.0CNY

  • Detail
  • Alfa Aesar

  • (H66294)  1-Benzylindole-3-carboxylic acid, 95%   

  • 27018-76-4

  • 5g

  • 3360.0CNY

  • Detail
  • Aldrich

  • (B8875)  1-Benzylindole-3-carboxylicacid  

  • 27018-76-4

  • B8875-1G

  • 804.96CNY

  • Detail

27018-76-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-BENZYLINDOLE-3-CARBOXYLIC ACID

1.2 Other means of identification

Product number -
Other names INDOLE-3-CARBOXYLIC ACID,1-BENZYL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27018-76-4 SDS

27018-76-4Relevant articles and documents

Pd(II)-Catalyzed asymmetric oxidative annulation of N-alkoxyheteroaryl amides and 1,3-dienes

Zhang, Tao,Shen, Hong-Cheng,Xu, Jia-Cheng,Fan, Tao,Han, Zhi-Yong,Gong, Liu-Zhu

supporting information, p. 2048 - 2051 (2019/03/29)

The first Pd(II)-catalyzed asymmetric oxidative annulation of N-alkoxyaryl amides and 1,3-dienes is reported, which features particular applicability for quick assembly of different types of chiral heterocycles with high yields and enantioselectivities. A novel chiral pyridine-oxazoline bearing a methoxyl group at the C-5 position and a gem-dimethyl group on the oxazoline moiety was found to be crucial for conversion.

Me2AlCl-mediated carboxylation, ethoxycarbonylation, and carbamoylation of indoles

Nemoto, Koji,Tanaka, Shinya,Konno, Megumi,Onozawa, Satoru,Chiba, Masafumi,Tanaka, Yuuki,Sasaki, Yosuke,Okubo, Ryo,Hattori, Tetsutaro

, p. 734 - 745 (2016/01/15)

Various 1-methyl-, 1-triisopropylsilyl-, and 1-benzylindoles are carboxylated under CO2 pressure (3.0 MPa) with the aid of 1.0 molar equiv of Me2AlCl to give 1-substituted indole-3-carboxylic acids in good to excellent yields. Mechanistic studies suggest that the intermediate, an indol-3-ylaluminum ate complex, was reversibly formed by electrophilic addition of Me2AlCl to the substrate followed by deprotonation of the resulting adduct. This method is successfully extended to alkoxycarbonylation with ethyl chloroformate and carbamoylation with naphthalen-1-yl isocyanate, which afford ethyl indole-3-carboxylates and N-naphthalen-1-ylindole-3-carboxamides, respectively.

Hydroxamic acids block replication of hepatitis c virus

Ai, Teng,Xu, Yanli,Qiu, Li,Geraghty, Robert J.,Chen, Liqiang

, p. 785 - 800 (2015/01/30)

Intrigued by the role of protein acetylation in hepatitis C virus (HCV) replication, we tested known histone deacetylase (HDAC) inhibitors and a focused library of structurally simple hydroxamic acids for inhibition of a HCV subgenomic replicon. While known HDAC inhibitors with varied inhibitory profiles proved to be either relatively toxic or ineffective, structure-activity relationship (SAR) studies on cinnamic hydroxamic acid and benzo[b]thiophen-2-hydroxamic acid gave rise to compounds 22 and 53, which showed potent and selective anti-HCV activity and therefore are promising starting points for further structural optimization and mechanistic studies.

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