1363773-45-8

Basic information

• Product Name: 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide
• Synonyms: 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide
• CAS NO: 1363773-45-8
• Molecular Weight: 448.419
• Mol File: 1363773-45-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide(1363773-45-8)
• EPA Substance Registry System: 3-[4-(3-Chlorophenyl)piperazino]propyl [5-(4-chlorophenyl)-4H-1,2,4-triazol-3-yl]sulfide(1363773-45-8)

Safety Data

• Hazardous Substances Data: 1363773-45-8(Hazardous Substances Data)

Upstream product

• 74-11-3 para-chlorobenzoic acid 
• 6640-24-0 N-(m-chlorophenyl)piperazine 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 64310-32-3 1-(4-chlorobenzoyl)thiosemicarbazide 
• 39577-43-0 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine 
• 26028-65-9 5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 1126-46-1 Methyl 4-chlorobenzoate 

Relevant articles and documents

Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

A series of 3-[3-[4-(substituted)-1-cyclicamine] propyl]thio-5- substituted[1,2,4]triazoles (8a-m) and 2-[3-[4-(substituted)-1-cyclicamine] propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a-h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity. Springer Science+Business Media 2013.