136449-55-3

Usage

Chemical Properties

white low melting solid

Upstream product

• 136449-69-9 [1,1′-biphenyl]-4-yldiisopropylsilane 
• 1201-71-4 4-biphenyllithium 
• 92-52-4 biphenyl 
• 2227-29-4 chlorodiisopropylsilane 
• 7751-38-4 Diisopropylsilyl dichloride 
• 92-66-0 4-bromo-1,1'-biphenyl 

Relevant academic research and scientific papers

Crown Ether Nucleophilic Catalysts (CENCs): Agents for Enhanced Silicon Radiofluorination

New bifunctional phase transfer agents were synthesized and investigated for their abilities to promote rapid fluorination at silicon. These agents, dubbed crown ether nucleophilic catalysts (CENCs), are 18-crown-6 derivatives containing a side-arm and a potentially nucleophilic hydroxyl group. These CENCs proved efficacious in the fluorination of hindered silicon substrates, with fluorination yields dependent on the length of linker connecting the metal chelating unit to the hydroxyl group. The efficacy of these CENCs was also demonstrated for rapid radiofluorination under mild conditions for eventual application in molecular imaging with positron emission tomography (PET). The hydrolysis-resistant aryl silicon fragment is promising as a convenient synthon for labeling potential PET radiotracers.

Amino acid-promoted C-H alkylation with alkylboronic acids using a removable directing group

Palladium-catalyzed C-H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp3)-H bonds with alkylboronic acids.

Biphenyldialkylsilyl chlorides: Reagents for the formation of crystalline derivatives of small terminal alkynes

Biphenyldimethylsilyl chloride (BDMS-Cl) and biphenyldiisopropylsilyl chloride (BDIPS-Cl) are readily prepared reagents for the introduction of the BDMS and BDIPS protecting groups onto small terminal alkynes, leading to stable, solid, and easily recrystallizable derivatives of these thermally unstable molecules.