136450-05-0

Basic information

• Product Name: methyl 4-(4-Phenylbutoxy)benzoate
• Synonyms: methyl 4-(4-Phenylbutoxy)benzoate
• CAS NO: 136450-05-0
• Molecular Weight: 284.355
• Mol File: 136450-05-0.mol

Chemical Properties

• CAS DataBase Reference: methyl 4-(4-Phenylbutoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(4-Phenylbutoxy)benzoate(136450-05-0)
• EPA Substance Registry System: methyl 4-(4-Phenylbutoxy)benzoate(136450-05-0)

Safety Data

• Hazardous Substances Data: 136450-05-0(Hazardous Substances Data)

Upstream product

• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 108-90-7 chlorobenzene 
• 1589-82-8 phenylmagnesium bromide 
• 13633-25-5 1-Bromo-4-phenylbutane 
• 623-03-0 4-Cyanochlorobenzene 
• 3360-41-6 4-phenyl-butan-1-ol 
• 67-56-1 methanol 
• 138631-41-1 4-(4-phenylbutoxy)benzonitrile 
• 60-29-7 diethyl ether 
• 1972-28-7 diethylazodicarboxylate 
• 4830-93-7 1-Chloro-4-phenylbutane 

Downstream Products

• 103176-67-6 ONO-RS-347 
• 103177-37-3 pranlukast 
• 30131-16-9 4-(4-phenyl-1-butoxy)benzoic acid 

Relevant articles and documents

Preparation method of 4-(4-phenylbutoxy) benzoic acid

The invention relates to a preparation method of 4-(4-phenylbutoxy) benzoic acid, which specifically comprises the following steps: a, performing a reaction on gamma-chlorobutanone with p-hydroxybenzoate under the catalysis of alkali to generate a compoun

Preparation method for p-phenylbutoxybenzoic acid

The invention provides a preparation method for p-phenylbutoxybenzoic acid, belonging to the field of organic synthesis. According to the invention, palladium-based catalytic coupling is adopted, andthe Grignard reaction and the Friedel-Craft reaction are avoided, thereby avoiding the production of blue-green copper ion wastewater and generation of a large amount of acidic wastewater due to usageof aluminum trichloride; the preparation method of the invention is friendly to environment, simple in synthesis route and high in the yield of each step; and halogeno-benzene is used for replacing more expensive phenylmagnesium bromide and used as a starting material, so the preparation cost of p-phenylbutoxybenzoic acid is lowered. The p-phenylbutoxybenzoic acid obtained in the invention has good crystal form, high purity and good solubility. The data of embodiments of the invention show that the total yield of p-phenylbutoxybenzoic acid prepared in the invention is 60% or above, and the HPLC purity of p-phenylbutoxybenzoic acid is 99.9% or above.

Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators

Selective optimization of side activities (SOSA) offers an alternative entry to early drug discovery and may provide rapid access to bioactive new chemical entities with desirable properties. SOSA aims to reverse a drug's side activities through structural modification and to design out the drug's original main action. We identified a moderate side activity for the cysteinyl leukotriene receptor 1 (CysLT1R) antagonist pranlukast on the farnesoid X receptor (FXR). Systematic structural modification of the drug allowed remarkable optimization of its partial FXR agonism to sub-nanonmolar potency. The resulting FXR modulators lack any activity on CysLT1R and are characterized by high selectivity, high metabolic stability, and low toxicity. With their favorable in vitro profile, these SOSA-derived FXR modulators constitute a new FXR ligand chemotype that appears suitable for further preclinical evaluation.

Bent-core mesogens with an aromatic unit at the terminal position

Bent-core liquid crystals with a naphthalene central unit and an aromatic ring at the terminal position of molecular tails were synthesised with the aim of enhancing nanosegregation. It was found that the length of the spacer between the rigid core and the terminal aromatic moiety had a profound influence on the liquid crystal polymorphism. The homologues with short spacers exhibited nematic and columnar phases, whereas the homologue with long spacers exhibited a tilted lamellar phase with a liquid-like in-plane order, indicating an unusual morphology of the densely packed toroidal objects. The morphology can be changed to twisted ribbons by small additives adsorbed on the membrane surface. This is the first example of twisted ribbons constructed by a lamellar system with no long-range in-plane order.

A 4-( benzene butoxy) benzoic acid synthesis method

The invention relates to a method for chemically synthetizing 4-(benzene butoxy) benzoic acid. The method comprises the following steps: causing benzene butanol as shown in a formula (II) to carry out thermal reaction in the presence of alkali, and then i

METHOD FOR PRODUCING CARBOXYLIC ACID COMPOUND

The present invention provides a method for producing a compound represented by the formula (3): wherein n is an integer of 1 to 6, characterized by the steps of hydrolyzing a solution containing an ester compound represented by the formula (1): wherein R is a lower alkyl group and n is an integer of 1 to 6, and a compound represented by the formula (2): wherein R is as defined above, adjusting the pH of the resulting solution to pH 4 to 8, and then subjecting to phase separation to obtain an organic layer containing the carboxylic acid of formula (3).

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.

Process for preparing tetrazol-5-yl substituted benzopyran compounds

A process for preparing substituted benzopyran derivatives which comprises a final step cyclisation of the corresponding open-chain intermediates.

New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships

(p-Amylcinnamoyl)anthranilic acid (3a) had moderate antagonist activities against LTD4-induced smooth muscle contraction on guinea pig ileum and LTC4-induced bronchoconstriction in anesthetized guinea pigs. Modifications were made in the hydrophobic part (cinnamoyl moiety) and the hydrophilic part (anthranilate moiety) of 3a. A series of 8-(benzoylamino)-2-tetrazol-5-yl-1,4-benzodioxans and 8-(benzoylamino)-2-tetrazol-5-yl-4-oxo-4H-1-benzopyrans were revealed to be potent antagonists of leukotrienes C4 and D4. Among both series, ONO-RS-347 (18k) and ONO-RS411 (19h) were the most potent and orally active antagonists, respectively. Structure-activity relationships are discussed.