Synthesis of 10-substituted "open-chain" analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF, lometrexol)

DOI: 10.1016/S0040-4020(01)80575-5

Source and publish data:

Tetrahedron p. 19 - 32 (1992)

Update date:2022-08-03

Topics:

Authors:

Taylor, Edward C.

Schrader, Thomas H.

Walensky, Loren D.

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Article abstract of DOI:10.1016/S0040-4020(01)80575-5

Several novel and very potent folate antimetabolites, structurally based upon our previously described "open-chain" version of DDATHF but carrying 1-carbon substituents in the 10-position, have been synthesized. A key synthetic sequence involving a pallad

Full text of DOI:10.1016/S0040-4020(01)80575-5

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