1365271-95-9

Upstream product

• 122-51-0 orthoformic acid triethyl ester 
• 401567-10-0 4-fluoro-N₁-methylbenzene-1,2-diamine 
• 704-05-2 (4-fluoro-2-nitrophenyl)-(methyl)amine 
• 124-38-9 carbon dioxide 
• 367-31-7 4-fluoro-1,2-phenylenediamine 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 64-18-6 formic acid 

Downstream Products

• 1541022-45-0 C₁₄H₁₁FN₂ 
• 1612157-19-3 C₁₅H₁₃FN₂ 
• 1612157-21-7 C₁₅H₁₃FN₂O 
• 1539720-74-5 C₁₄H₁₀F₂N₂ 
• 1612157-22-8 C₁₆H₁₃FN₂ 

Relevant academic research and scientific papers

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

Endogenous X-C=O species enable catalyst-free formylation prerequisite for CO2reductive upgrading

CO2, the main component of greenhouse gas, is currently developed as a promising surrogate of carbon feedstock. Among various conversion routes, CO2undergoing catalytic reduction can furnish hydrogen/energy carriers and value-added chemicals, while specific metal-containing catalysts or organocatalysts are often prerequisite for smooth proceeding of the involved reaction processes. In this work, both formic acid and N-containing benzoheterocyclic compounds (including various benzimidazoles, benzothiazole, and benzoxazole) along with silanols could be synthesized with high yields (>90%) from catalyst-free reductive upgrading of CO2under mild conditions (50 °C). The endogenous X-CO species, derived from the N-methyl-substituted amide-based solvent [Me2N-C(O)-R], especially PolarClean, and O-formyl group [O-C(O)-H] of in situ formed silyl formate, were found to play a prominent promotional role in the activation of the used hydrosilane for reductive CO2insertion, as demonstrated by density functional theory (DFT) calculations and isotopic labeling experiments. Moreover, reaction mechanisms and condition-based sensitivity assessment were also delineated.

Photoreactivity of monofluorinated 2-azidobenzimidazoles towards carboxylic acids

Aiming at the development of new photolabeling agents, the synthesis and photoreactivity of all monofluorinated derivatives of 2-azido-1-methylbenzimidazole are described. In the case of 4-, 5-, or 7-fluorination, irradiation in the presence of carboxylic