1365552-53-9Relevant academic research and scientific papers
Catalytic Asymmetric Carbonylation of Prochiral Sulfonamides via C-H Desymmetrization
Bai, Xing-Feng,Mu, Qiu-Chao,Xu, Zheng,Yang, Ke-Fang,Li, Li,Zheng, Zhan-Jiang,Xia, Chun-Gu,Xu, Li-Wen
, p. 1431 - 1436 (2019)
An enantioselective oxidative C-H/N-H carbonylation process was developed in this work. A bimetallic Pd/Cu-based catalyst system was found to catalyze enantioselective C(sp2)-H carbonylation of prochiral arylsulfonamides via desymmetrization pr
Chiral-Directing-Group-Assisted Rhodium(III)-Catalyzed Asymmetric Addition of Inert Arene C?H Bond to Aldimines with Subsequent Intramolecular Cyclization
Cai, Xuhong,Chen, Wenkun,Nie, Ruifang,Wang, Jun
, p. 16611 - 16615 (2021/10/19)
By using a chiral directing group, an asymmetric rhodium(III)-catalyzed C?H bond addition to aldimines followed by intramolecular cyclization to form chiral isoindolinones has been achieved (up to 68 % yield, up to 93 % ee). A three-component variant that resembles Mannich reaction was also realized (41 % yield, 83 % ee). Product elaborations and preliminary mechanistic studies were described.
Chiral isoindoline compound and preparation method thereof
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Paragraph 0069; 0070-0080; 0083-0088; 0091-0094, (2019/03/08)
The invention belongs to the field of organic chemicals, and provides a chiral isoindoline compound and a preparation method thereof to solve the problem that an existing synthesized chiral isoindoline compound has strict reaction conditions. The preparat
Rh(I)-catalyzed asymmetric synthesis of 3-substituted isoindolinones through co gas-free aminocarbonylation
Fujioka, Masahiko,Morimoto, Tsumoru,Tsumagari, Takayuki,Tanimoto, Hiroki,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi
experimental part, p. 2911 - 2923 (2012/05/05)
A highly efficient and accessible synthesis of chiral 3-substituted isoindolinone frameworks is described. The synthesis involved the Rh(I)-catalyzed asymmetric arylation of boronic acids to 2-halobenzaldimines and the subsequent Rh(I)-catalyzed intramolecular aminocarbonylation of the resulting 2-halobenzylamines using an aldehyde as the carbonyl source. The method tolerates a variety of functional groups, yielding isoindolinone derivatives in moderate to high yields with high ee-values. In addition, two Rh(I)-catalyzed transformations could be efficiently accomplished in a one-pot sequence to give chiral isoindolinones by the simple addition of a ligand and an aldehyde after the Rh(I)-catalyzed asymmetric arylation.
