136701-86-5

Upstream product

• 53440-57-6 3-phenylbenzo[d]isothiazole-1,1-dioxide 
• 81-07-2 saccharin 
• 136481-64-6 N-tert-butyl-2-(α-hydroxybenzyl)benzenesulphonamide 
• 100-52-7 benzaldehyde 
• 769196-03-4 2-benzyl-N-(tert-butyl)benzenesulfonamide 
• 100-39-0 benzyl bromide 
• 2512-24-5 N-tert-butylbenzenesulfonamide 
• 769196-05-6 2-benzylbenzenesulfonamide 
• 256221-51-9 C₂₂H₂₃NO₅S 

Downstream Products

• 53440-57-6 3-phenylbenzo[d]isothiazole-1,1-dioxide 

Relevant academic research and scientific papers

Efficient visible-light photocatalytic aerobic oxidation of cyclic sulfamides to imines

A highly efficient photocatalytic aerobic oxidation of cyclic sulfamides to synthesize cyclic N-sulfonyl imines with Ir(ppy)2(dtbpy)PF6 as photocatalyst is reported. These environmentally friendly transformations exihibit good to excellent isolated yields and good generality with respect to both five-membered and six-membered cyclic sulfamides.

B(C6F5)3-Catalyzed Reduction of Cyclic N-Sulfonyl Ketimines

A metal-free method for reduction of cyclic N-sulfonyl ketimines catalyzed by B(C6F5)3, using commercially available methylphenylsilane as a reducing reagent under mild conditions has been developed. This reductive protoco

Cobalt-Catalyzed Transfer Hydrogenation of α-Ketoesters and N-Cyclicsulfonylimides Using H2O as Hydrogen Source

A Co-catalyzed effective transfer hydrogenation of various α-ketoesters and N-cyclicsulfonylimides by safe and environmentally benign H2O as hydrogen source is described. The reaction used easily available and easy to handle zinc metal as a reductant. Interestingly, the catalytic system does not require ligand for reduction of N-cyclicsulfonylimides. (Figure presented.).

An N-heterocyclic carbene iridium catalyst with metal-centered chirality for enantioselective transfer hydrogenation of imines

A cyclometalating N-heterocyclic carbene iridium complex featuring metal-centered chirality was designed and used for the asymmetric transfer hydrogenation (ATH) of imines. Four strongly σ-donating carbon-based substituents (2 carbenes and 2 phenyl moieti

Synthesis of chiral sultams via palladium-catalyzed intramolecular asymmetric reductive amination

A novel palladium-catalyzed intramolecular reductive amination of ketones with weakly nucleophilic sulfonamides has been developed in the presence of a Br?nsted acid, giving a wide range of chiral γ-, δ-, and ε-sultams in high yields and up to 99% of enan

Highly enantioselective synthesis of sultams via Pd-catalyzed hydrogenation

(Chemical Equation Presented) Using pd(cf3co2) 2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high

Intramolecular asymmetric amidations of sulfonamides and sulfamates catalyzed by chiral dirhodium(II) complexes

Enantioselective intramolecular amidation of aliphatic sulfonamides was achieved for the first time by means of chiral carboxylatodirhodium(II) catalysts in conjunction with PhI(OAc)2 and MgO in high yields and with enantioselectivities of up to 66% (Scheme 3, Table 1). The best results were obtained with [Rh2{(S)-nttI)4] and [Rh 2{(R)-ntv)4] as catalysts ((S)-nttl = (αS)-α- (tert-butyl)-1,3-dioxo-2H-benz[de]isoquinoline-2-acetato, (R)-nto = (αR)-α-isopropyl-1,3-dioxo-2H-benz[de] isoquinoline-2-acetato). In addition, these carboxylatodirhodium(II) catalysts were also efficient in intramolecular amidations of aliphatic sulfamates esters, although the enantioselectivity of these latter reactions was significantly lower (Scheme 4, Table 3).

Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions

Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections

Photoisomerization of Sultams Derived from Saccharin; Part 4: Generation of Cyclic Sulfine Hydroxamic Acids

Various areno[d]annulated 3-mono- and 3,3-disubstituted 2,3-dihydro[1,2]benzisothiazole 1,1-dioxides undergo a facile rearrangement into the corresponding 2,3-dihydro-2-hydroxy[1,2]benzisothiazole 1-oxides upon irradiation at 254 nm in methanol. The latter represent a new, but labile functional group, i.e. the cyclic version of the sulfine hydroxamic acid. When C-3 in the starting materials is substituted by one methyl or phenyl only, that photoisomer is formed preferentially which has the sulfoxide O atom in an anti-orientation to the said substituent. 2-Alkoxymethyl substituted starting materials show the same type of formal oxygen shift. The structures of all photoproducts have been assigned largely from 1H NMR data and unambiguously corroborated by X-ray crystal structure analyses of two photoproducts.