136763-93-4

Upstream product

• 192188-84-4 acetic acid 2,4-dimethoxy-3-methyl-5-nitrophenyl ester 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 
• 5673-07-4 2,6-dimethoxytoluene 
• 60512-80-3 2′,4′-dimethoxy-3′-methylacetophenone 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 

Downstream Products

• 111223-14-4 5-amino-2,4-dimethoxy-3-methylphenol 
• 206766-57-6 1-allyloxy-2,4-dimethoxy-3-methyl-5-nitro-benzene 
• 111223-13-3 (2aS,3R,7cR,7dS)-4-Benzyloxy-5,7-dimethoxy-6-methyl-3-((Z)-2-phenyl-2-trimethylsilanyloxy-vinyl)-2a,3,7c,7d-tetrahydro-2-oxa-7b-aza-benzo[f]cyclopropa[cd]inden-1-one 
• 123266-78-4 (E)-3-(2-Azido-6-benzyloxy-3,5-dimethoxy-4-methyl-phenyl)-1-phenyl-propenone 
• 111223-16-6 2-Azido-6-benzyloxy-3,5-dimethoxy-4-methyl-benzaldehyde 
• 111223-15-5 3-Azido-2-hydroxymethyl-4,6-dimethoxy-5-methyl-phenol 
• 113727-26-7 2,3,5-trimethoxy-4-methyl-6-nitrobenzenemethanol 
• 136763-85-4 (+/-)-(E)-2,3,5-trimethoxy-α-(1-methoxy-1,3-butadienyl)-4-methyl-6-nitrobenzenemethanol 
• 113727-24-5 4-methyl-6-nitro-2,3,5-trimethoxybenzaldehyde 
• 115920-42-8 1,4-dihydro-1-hydroxy-3,6-dimethoxy-1,2-dimethyl-9H-carbazol-4-one 
• 206766-62-3 2-(4-benzyloxy-3-formyl-5,7-dimethoxy-6-methyl-indol-1-ylmethyl)-3-(2-thioxo-2H-pyridine-1-carbonyl)-aziridine-1-carboxylic acid tert-butyl ester 
• 206766-49-6 (2R,3S)-3-(4-Benzyloxy-3-formyl-5,7-dimethoxy-6-methyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 206766-61-2 (2R,3S)-3-(4-Benzyloxy-3-formyl-5,7-dimethoxy-6-methyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 
• 206766-50-9 (2S,3R)-2-(4-Benzyloxy-3-formyl-5,7-dimethoxy-6-methyl-indol-1-ylmethyl)-3-bromo-aziridine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

A Highly Efficient Pd(PPh3)4-Catalyzed Suzuki Cross-Coupling Method for the Preparation of 2-Nitrobiphenyls from 1-Chloro-2-nitrobenzenes and Phenylboronic Acids

A simple and efficient method for Suzuki cross-coupling of highly substituted and congested 1-chloro-2-nitrobenzene with phenylboronic acid was developed, investigated, and optimized. The reaction conditions comprises a mixture of MeOH and water (4:1) as the reaction medium, readily available and cheap Pd(PPh3)4 as catalyst, sodium carbonate as base, and microwave heating, which affords a fast reaction rate with good outcomes. The procedure was proven to have high functional group tolerance with phenylboronic acid and for 1-chloro-2-nitrobenzene and thus is a general method for the synthesis of 2-nitrobiphenyl. The target scaffold, 2-nitrobiphenyls, was produced in excellent yields with excellent selectivities in all cases. An efficient microwave-assisted and Pd(PPh3)4-catalyzed Suzuki cross-coupling method for the synthesis of 2-nitrobiphenyls from 1-chloro-2-nitrobenzenes and phenylboronic acids is disclosed. The method exhibits excellent selectivity and fast reaction rates, provides high to excellent yields, and tolerates both electron-withdrawing and -donating groups.

TREATMENT OR PREVENTION OF LEUKAEMIA

The present invention provides compounds for use in the treatment or prevention of leukaemia which are based on a 2-amino-[1,1']-bipbenyl or corresponding carbazole scaffold, in particular, it provides the following compounds of formula (I), their stereoi

Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest

A previously designed and developed 12-step total synthesis that includes [1,1′-biphenyl]-2-amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of

Carbazomycin G: Method Development and Total Synthesis

A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the initial simple substrate and intermediates. To rea

Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4] benzoquinone

A telescoped process for the preparation of 2-methoxy-3-methyl-[1,4] benzoquinone is disclosed. When this novel process is compared to the prevailing method that utilizes Na2Cr2O7 as the oxidant, the novel process represen

Iron-mediated synthesis of carbazomycin G and carbazomycin H, the first carbazole-1,4-quinol alkaloids from Streptoverticillium ehimense

The total synthesis of the carbazole-1,4-quinol alkaloids carbazomycin G (7) and carbazomycin H (8) was achieved by a highly convergent iron-mediated construction of the carbazole framework. Electrophilic substitution of the arylamine 15 using the iron co

Transition metal complexes in organic synthesis, Part 38. First total synthesis of carbazomycin G and H

The first total synthesis of the carbazole quinol alkaloids carbazomycin G and H has been achieved by a highly convergent synthesis using an iron-mediated construction of the carbazole nucleus as key-step.

SYNTHETIC APPROCHES TOWARD MITOMYCINS. I. STEREOSELECTIVE SYNTHESIS OF A TETRACYCLIC INTERMEDIATE.

A highly efficient synthesis of a tetracyclic intermediate 5 to the antitumor antibiotics AX-2 4, mitimycin A 2, and C 1 is described.