192188-84-4Relevant academic research and scientific papers
TREATMENT OR PREVENTION OF LEUKAEMIA
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, (2021/04/23)
The present invention provides compounds for use in the treatment or prevention of leukaemia which are based on a 2-amino-[1,1']-bipbenyl or corresponding carbazole scaffold, in particular, it provides the following compounds of formula (I), their stereoi
Hit to Leads with Cytotoxic Effect in Leukemic Cells: Total Synthesis Intermediates as a Molecule Treasure Chest
Bj?rsvik, Hans-René,Gjertsen, Bj?rn Tore,Elumalai, Vijayaragavan
, p. 862 - 870 (2020/05/05)
A previously designed and developed 12-step total synthesis that includes [1,1′-biphenyl]-2-amine and carbazole intermediates and that ultimately produces the carbazole alkaloid carbazomycin G was exploited as a screening compound library with the goal of
Carbazomycin G: Method Development and Total Synthesis
Elumalai, Vijayaragavan,Gambarotti, Cristian,Bj?rsvik, Hans-René
, p. 1984 - 1992 (2018/05/15)
A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the initial simple substrate and intermediates. To rea
Efficient and green telescoped process to 2-methoxy-3-methyl-[1,4] benzoquinone
Rodriguez Gonzalez, Raquel,Gambarotti, Cristian,Liguori, Lucia,Bjorsvik, Hans-Rene
, p. 1703 - 1706 (2007/10/03)
A telescoped process for the preparation of 2-methoxy-3-methyl-[1,4] benzoquinone is disclosed. When this novel process is compared to the prevailing method that utilizes Na2Cr2O7 as the oxidant, the novel process represen
Iron-mediated synthesis of carbazomycin G and carbazomycin H, the first carbazole-1,4-quinol alkaloids from Streptoverticillium ehimense
Knoelker, Hans-Joachim,Froehner, Wolfgang,Reddy, Kethiri R.
, p. 740 - 746 (2007/10/03)
The total synthesis of the carbazole-1,4-quinol alkaloids carbazomycin G (7) and carbazomycin H (8) was achieved by a highly convergent iron-mediated construction of the carbazole framework. Electrophilic substitution of the arylamine 15 using the iron co
Transition metal complexes in organic synthesis, Part 38. First total synthesis of carbazomycin G and H
Knoelker, Hans-Joachim,Froehner, Wolfgang
, p. 4051 - 4054 (2007/10/03)
The first total synthesis of the carbazole quinol alkaloids carbazomycin G and H has been achieved by a highly convergent synthesis using an iron-mediated construction of the carbazole nucleus as key-step.
SYNTHETIC APPROCHES TOWARD MITOMYCINS. I. STEREOSELECTIVE SYNTHESIS OF A TETRACYCLIC INTERMEDIATE.
Fukuyama, Tohru,Yang, Lihu
, p. 6299 - 6300 (2007/10/02)
A highly efficient synthesis of a tetracyclic intermediate 5 to the antitumor antibiotics AX-2 4, mitimycin A 2, and C 1 is described.
