13681-87-3Relevant articles and documents
Mechanically activated solid-phase synthesis of copper(II), zinc(II), and cadmium(II) diethyldithiocarbamates
Petrova,Makhaev
, p. 865 - 870 (2007)
The mechanically activated solid-phase reaction of copper, zinc, and cadmium chlorides with sodium diethyldithiocarbamate is studied. The course of the process and the extent of reaction are studied as affected by the parameters of the mechanical activati
Antioxidant potential and secondary reactivity of bisfdiphenyl(2-pyridyl)phosphinogcopper(II) complex
Khan, Ezzat,Shahzad, Adnan,Tahir, Muhammad Nawaz,Noor, Awal
, p. 1299 - 1308 (2018)
Copper-based complexes with the general formulas [Cu(L)2]Cl2(1) and [Cu2L2 (μ2-L)μ2-Cl2](2) and a mixed-ligand anionic complex [Cu(L)2 dedtc][LCl] (3b), where L = diphenyl(2-pyridyl)phosphine and dedtc = diethyldithiocarbamate, were synthesized and structurally characterized. X-ray analysis revealed that the coordination environment around the copper atom in complexes 1-3 is distorted tetrahedral. In monomeric complexes 1 and 3b both diphenyl(2-pyridyl) phosphine ligands are monodentate and are coordinated through the P-atom. In complex 3b two phosphine ligands are attached to copper through the P-atom. The third phosphine ligand acts as a bridged ligand, coordinated to the metal centers through the P-atom and N-atom. Complexes 1 and 3b were tested for radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) as a free radical. A prominent color change after mixing the solution of complex 1 and DPPH was observed, indicating the efficiency of the compound as antioxidant.
Disulfiram and Its Copper Chelate Attenuate Cisplatin-Induced Acute Nephrotoxicity in Rats Via Reduction of Oxidative Stress and Inflammation
Khairnar, Shraddha I.,Mahajan, Umesh B.,Patil, Kalpesh R.,Patel, Harun M.,Shinde, Sachin D.,Goyal, Sameer N.,Belemkar, Sateesh,Ojha, Shreesh,Patil, Chandragouda R.
, p. 174 - 184 (2020)
The use of cisplatin (CP) in chemotherapy of resistant cancers is limited due to its dose-dependent nephrotoxicity. Disulfiram (DSF), the aversion therapy for alcoholism, has recently emerged as an anticancer and chemopreventive agent. Its anticancer activity is potentiated in the presence of copper. However, such use of copper leads to several adverse effects. In the present study, the protective effect of DSF and its copper chelate (Cu-DEDC) against CP-induced nephrotoxicity in rats was evaluated. Nephrotoxicity was induced by a single intraperitoneal injection of CP (5?mg/kg). The treatment groups included control (vehicle treated), CP (CP-treated), CP + DSF (CP followed by DSF), CP + DSF + Cu (CP followed by DSF and CuCl2), CP + Cu-DEDC (CP followed by Cu-DEDC), and CP + AMF (amifostine pre-treated and CP-treated). The DSF, Cu-DEDC, and CuCl2 were administered orally at 50?mM/kg/day dose for 5?days post CP injection. AMF served as a standard chemo protectant, administered intravenously 30?min prior to CP. The markers of oxidative stress, inflammation, and kidney function estimated on the 6th day revealed that both DSF and Cu-DEDC significantly attenuated the CP-induced rise in the serum/urine creatinine and blood urea nitrogen (BUN). The CP-induced rise in serum alkaline phosphatase (ALPase) was reversed by these drugs. Both drugs reduced the levels of malondialdehyde and nitric oxide (NO) in kidney tissues. These drugs reversed CP-induced depletion of SOD, catalase, and GSH in the kidneys. There was a significant reduction in the CP-induced TNF-α and IL-1β production along with prevention of histological alterations. Above observations indicate that DSF and Cu-DEDC may have significance as adjuvants to protect against CP-induced nephrotoxicity.
Charge-transfer photochemistry of copper(II) dithiocarbamate mixed-ligand complexes
Jeliazkova,Doicheva
, p. 1277 - 1282 (1996)
The photoredox behaviour of copper(II) diethyldithiocarbamate mixed-ligand complexes, Cu(Et2dtc)X (X = Cl, ClO4, NO3), is characterized by strongly allowed ligand-to-metal charge transfer (LMCT) transition in the visible s
On the interaction of copper(ii) with disulfiram
Lewis, David J.,Deshmukh, Parikshit,Tedstone, Aleksander A.,Tuna, Floriana,O'Brien, Paul
, p. 13334 - 13337 (2014)
In combination with copper(ii) ions, disulfiram (DSF) has been reported to be a potentially potent anticancer agent based on in vitro results. The interaction of DSF with copper(ii) chloride in solution has been studied using a range of spectroscopic techniques. There is strong evidence for the rapid formation of the bis(N,N-diethyl dithiocarbamato)copper(ii) complex in situ. Kinetic experiments were used to determine rate laws for the reaction that give insight into the mechanism of the process which may help to explain the observed in vitro cytotoxicity. This journal is
Tetsumi, T.,Sumi, M.,Tanaka, M.,Shono, T.
, p. 1439 - 1442 (1985)
A facile synthesis of Cu(II) diethyldithiocarbamate from monovalent copper-cysteamine and disulfiram
Cao, Derong,Chen, Zeliang,Ran, Xueguang,Tang, Hao,Wang, Lingyun
, (2022/02/02)
The copper(II) diethyldithiocarbamate (Cu(DDC)2) complex prepared from disulfiram and Cu(II) species has shown excellent anticancer activity. However, general synthetic methods largely rely on tedious procedures and limited reaction types with undesirable by-products. In this paper, we reported an efficient and atom-economic synthesis of Cu(DDC)2 from disulfiram and monovalent copper cysteamine (Cu(I)Cy) via a one-step oxidation–reduction reaction. Cu(DDC)2 was fully characterized by nuclear magnetic resonance (NMR), mass spectrometry (MS), infrared spectroscopy (IR), scanning electron microscope (SEM), X-ray diffraction (XRD), ultraviolet and visible (UV–Vis) spectrophotometry, X-ray photoelectron spectroscopy (XPS), electron paramagnetic resonance (EPR) and single crystal X-ray diffraction. The proposed reaction mechanism and the effect of reaction conditions on the Cu(DDC)2 synthesis were investigated. The photochemical reactions of Cu(DDC)2 was studied in acetone, DMF, toluene, CCl4, CHCl3 under 254, 365 nm alone or combined 254 & 365 nm irradiation based on UV–vis and EPR measurements. The photolysis rate followed in this order: CCl4 > CHCl3 > DMF > toluene > acetone. The final photolysis products in CHCl3 were DSF and Cu2(DDC)2Cl2.
