136850-73-2Relevant academic research and scientific papers
A stereoselective synthesis of (±)-pestalotin
Honda,Okuyama,Hayakawa,Kondoh,Tsubuki
, p. 1866 - 1868 (1991)
(±)-Pestalotin was synthesized by employing a stereoselective reduction of a 5-alkyltetronate derivative and a two-carbon elongation reaction of the aldehyde with ethyl diazoacetate in the presence of stannous chloride as key steps.
High Diastereoselection in the Aldol Reaction of the Bistrimethylsilyl Enol Ether of Methyl Acetoacetate with 2-Benzyloxyhexanal: Synthesis of (-)-Pestalotin
Hagiwara, Hisahiro,Kimura, Katsuhiko,Uda, Hisashi
, p. 693 - 700 (2007/10/02)
Aldol condensation of the bistrimethylsilyl enol ether of methyl acetoacetate, compound 2, with 2-benzyloxyhexanal 3c affords highly selectively (99:1) the syn-aldol adduct 4c in the presence of titanium tetrachloride.The stereocontrolled synthesis of (-)-pestalotin 7 has been achieved.
