110320-68-8

Upstream product

• 67-56-1 methanol 
• 616-05-7 2-bromohexanoic acid 
• 20194-18-7 sodium phenyl-methanolate 
• 68756-64-9 2-hydroxyhexanoic acid methyl ester 
• 100-39-0 benzyl bromide 
• 636-36-2 rac-2-hydroxyhexanoic acid 

Downstream Products

• 70326-39-5 α-benzyloxyhexanal 
• 54620-78-9 6-(1'-benzyloxypentyl)-5,6-dihydro-4-methoxypyran-2-one 
• 106225-84-7 2-(1'-benzyloxypentyl)-2,3-dihydro-6-methoxypyran-4-one 
• 136850-73-2 6-(1'-benzyloxypentyl)-5,6-dihydropyran-2,4(3H)-dione 
• 54620-78-9 6-(1'-benzyloxypentyl)-5,6-dihydro-4-methoxypyran-2-one 
• 66832-04-0 methyl 6-benzyloxy-5-hydroxy-3-oxodecanoate 
• 6920-22-5 (2S)-hexane-1,2-diol 
• 141554-36-1 2-(benzyloxy)hexan-1-ol 
• 110352-59-5 methyl (S)-2-benzyloxyhexanoate 

Relevant academic research and scientific papers

High Diastereoselection in the Aldol Reaction of the Bistrimethylsilyl Enol Ether of Methyl Acetoacetate with 2-Benzyloxyhexanal: Synthesis of (-)-Pestalotin

Aldol condensation of the bistrimethylsilyl enol ether of methyl acetoacetate, compound 2, with 2-benzyloxyhexanal 3c affords highly selectively (99:1) the syn-aldol adduct 4c in the presence of titanium tetrachloride.The stereocontrolled synthesis of (-)-pestalotin 7 has been achieved.

ENZYME-MEDIATED ASYMMETRIC HYDROLYSIS OF α-BENZYLOXYCARBOXYLIC ESTERS

Incubation of dl-α-benzyloxycarboxylic esters with grown cells of a bacterium, Corynebacterium equi IFO 3730, afforded the chiral esters of high optical purities via asymmetric hydrolysis.This reaction has been revealed to have a wide applicability to alkene- and arylalkene-carboxylic esters.