97-78-9

Usage

Uses

Used in Pharmaceutical Industry:
N-Lauroylsarcosine is used as a permeation enhancer in transdermal drug delivery formulations. It increases the fluidity of the stratum corneum lipid structure of the skin, allowing for improved penetration and absorption of drugs through the skin. This enhances the bioavailability and effectiveness of transdermal drug delivery systems.
Used in Cosmetics Industry:
N-Lauroylsarcosine is used as a foam booster and viscosity modifier in cosmetic formulations, such as shampoos, shower gels, and cleansers. Its amphiphilic properties allow it to create a rich lather and improve the texture and stability of the products.
Used in Personal Care Industry:
N-Lauroylsarcosine is used as a mild surfactant and emulsifier in personal care products, such as toothpaste and mouthwashes. Its mildness and ability to form stable emulsions make it suitable for sensitive applications, including oral care products.
Used in Food Industry:
N-Lauroylsarcosine can be used as an emulsifier and foaming agent in the food industry, particularly in the production of beverages and processed foods. Its ability to stabilize emulsions and create foams can improve the texture, appearance, and shelf life of various food products.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

Upstream product

• 112-16-3 n-dodecanoyl chloride 
• 107-97-1 sarcosine 
• 50-00-0 formaldehyd 
• 27563-67-3 lauric acid methylamide 
• 201230-82-2 carbon monoxide 
• 4316-73-8 sodium sarcosinate 
• 143-07-7 lauric acid 
• 111-82-0 methyl n-dodecanoate 
• 5616-32-0 (methylamino)acetonitrile 

Downstream Products

• 137-16-6 sodium N-lauroylsarcosinate 
• 13005-52-2 lauroyl ethyl sarcosine 

Relevant academic research and scientific papers

A high-purity N - lauroyl sarcosine preparation method

The invention discloses a high-purity N - lauroyl sarcosine preparation method, comprises the following steps: a) added to the reaction kettle in the sarcosine sodium solution, control under certain temperature and PH, within a certain time dropping undecanoyl and solvent of the mixed solution; b) after dropping, to step a) of the hydrochloric acid is added in the reaction solution, layered; c) organic phase cooling to a certain temperature crystallization, centrifugal, decompression drying to obtain high-purity N - lauroyl sarcosine. The adoption of the invention the resulting high purity N - lauroyl sarcosine used for preparing N - lauroyl sarcosine sodium does not contain the inorganic [...], the content is high, the reaction of the invention high yield, the operation is simple, and is suitable for industrial production.

Synthesis of N-Lauroyl Sarcosine by Amidocarbonylation: Comparing Homogeneous and Heterogeneous Palladium Catalysts

An improved system for the synthesis of N-acyl amino acids via Pd-catalyzed amidocarbonylation is reported. Utilizing inexpensive Pd black gives the industrially important surfactant N-lauroyl sarcosine in excellent yields (95%) on a multi-gram scale. Advantages of the new system include reusability, decreased process temperature, and, importantly, drastically decreased co-catalyst loading.

Method for synthesizing N-fatty acyl group amino acid

The invention discloses a method for synthesizing N-fatty acyl group amino acid. With fatty acid ester and amino-nitrile adopted as the raw materials, and with sodium methylate or sodium ethoxide adopted as the catalyst, the method comprises the following steps: heating under nitrogen protection; adjusting the pH value to be acid; after refrigeration, filtering the reaction liquid; carrying out reduced pressure distillation on the obtained solid; collecting the cut fraction, and placing in alkali liquor for hydrolysis, so as to obtain N-fatty acyl group amino acid salt; or collecting the cut fraction, and carrying out acidification to prepare N-fatty acyl group amino acid. According to the method, amino-nitrile and fatty acid ester are adopted as the raw materials to prepare high purity N-fatty acyl group amino acid, the raw materials are cheap, the equipment is simple, and waste water generated during the production process is less.

Methods for detection of nucleic acid sequences in urine

Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of diseases, such as cancer and pathogen infections, and detection of genetic predisposition to various diseases. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs. The invention also encompasses methods for evaluating the effects of environmental factors and aging on the genome.

Palladium-catalyzed amidocarbonylation - A new, efficient synthesis of N-acyl amino acids

For the first time palladium catalysts have been used successfully for the amidocarbonylation reaction. The activity of the cobalt catalysts that were used exclusively beforehand has now been exceeded by an order of magnitude, and the reaction can be performed under far milder conditions. Palladium-catalyzed amidocarbonylation reactions can now be used for the synthesis of a much wider range of N-acyl amino acids.

Syngas reactions XIV. Amidocarbonylation as a route to α-amidocarboxylic acids

The amidocarbonylation of olefin and aldehyde substrates has been applied to the synthesis of a variety of amidocarboxylic acids, including surface active agents (e.g.C14-C16 N-acyl-α-amino acids), specialty surfactants (such as the sarcosinates), intermediates for sweeteners (e.g. aspartame), food additives (e.g. glutamic acid), and certain chelating agents.Homogeneous cobalt and rhodium-based catalysts, modified, for example, with sulfoxide and bidentate phosphine ligands, have been tailored to the synthesis of each individual class of product.Process studies, including examinations of reaction rate, product selectivity, as well as catalyst stability, have been undertaken for N-acetylglycine and amido acid surfactant syntheses.

Melting Behaviour of Some Pure N-Acyl Amino Acids and Peptides

Fifty three tlc pure N-acyl amino acids were synthesized by Schotten-Baumann reaction from glc pure odd and even chain fatty acids and chromatographycally homogeneous amino acids and a few N-acyl peptides were prepared through the carboxylic carbonic anhydride intermediates.The melting points are reported and discussed.