97-78-9

Basic information

• Product Name: N-LAUROYLSARCOSINE
• Synonyms: n-methyl-n-(1-oxododecyl)-glycin;N-methyl-N-(1-oxododecyl)-Glycine;N-LAUROYLSARCOSINE FREE ACID;Glycine, N-methyl-N-(1-oxododecyl)-;n-lauroylsarcosine,neat;N-Lauroylsarkosin;N-Dodecanoyl-N-methylglycine, Sarkosyl L;Maprosyl L
• CAS NO: 97-78-9
• Molecular Formula: C₁₅H₂₉NO₃
• Molecular Weight: 271.4
• EINECS: 202-608-3
• Product Categories: Biochemistry;Nonionic Surfactants (for Biochemistry);Surfactants (for Biochemistry)
• Mol File: 97-78-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 45-49 °C
• Boiling Point: 413.2 °C at 760 mmHg
• Flash Point: 203.7 °C
• Appearance: white adhering powder
• Density: 0.97
• Vapor Pressure: 27.5Pa at 25℃
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: almost transparency in Methanol
• PKA: 3.62±0.10(Predicted)
• Water Solubility: 500mg/L at 25℃
• BRN: 1792084
• CAS DataBase Reference: N-LAUROYLSARCOSINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-LAUROYLSARCOSINE(97-78-9)
• EPA Substance Registry System: N-LAUROYLSARCOSINE(97-78-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 2811 6.1 / PGII
• WGK Germany: 1
• F: 3
• Hazardous Substances Data: 97-78-9(Hazardous Substances Data)

Usage

Uses

N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin

General Description

N-Lauroylsarcosine is an anionic surfactant with an ability to denature proteins. Due to its microbicidal property, N-lauroylsarcosine is being considered as a potent anti-microbicide in topical formulations,?especially against sexually transmitted diseases (STDs).

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

Upstream product

• 112-16-3 n-dodecanoyl chloride 
• 107-97-1 sarcosine 
• 50-00-0 formaldehyd 
• 27563-67-3 lauric acid methylamide 
• 201230-82-2 carbon monoxide 
• 111-82-0 methyl n-dodecanoate 
• 5616-32-0 (methylamino)acetonitrile 
• 143-07-7 lauric acid 
• 4316-73-8 sodium sarcosinate 

Downstream Products

• 137-16-6 sodium N-lauroylsarcosinate 
• 13005-52-2 lauroyl ethyl sarcosine 

Relevant articles and documents

A high-purity N - lauroyl sarcosine preparation method

The invention discloses a high-purity N - lauroyl sarcosine preparation method, comprises the following steps: a) added to the reaction kettle in the sarcosine sodium solution, control under certain temperature and PH, within a certain time dropping undecanoyl and solvent of the mixed solution; b) after dropping, to step a) of the hydrochloric acid is added in the reaction solution, layered; c) organic phase cooling to a certain temperature crystallization, centrifugal, decompression drying to obtain high-purity N - lauroyl sarcosine. The adoption of the invention the resulting high purity N - lauroyl sarcosine used for preparing N - lauroyl sarcosine sodium does not contain the inorganic [...], the content is high, the reaction of the invention high yield, the operation is simple, and is suitable for industrial production.

Method for synthesizing N-fatty acyl group amino acid

The invention discloses a method for synthesizing N-fatty acyl group amino acid. With fatty acid ester and amino-nitrile adopted as the raw materials, and with sodium methylate or sodium ethoxide adopted as the catalyst, the method comprises the following steps: heating under nitrogen protection; adjusting the pH value to be acid; after refrigeration, filtering the reaction liquid; carrying out reduced pressure distillation on the obtained solid; collecting the cut fraction, and placing in alkali liquor for hydrolysis, so as to obtain N-fatty acyl group amino acid salt; or collecting the cut fraction, and carrying out acidification to prepare N-fatty acyl group amino acid. According to the method, amino-nitrile and fatty acid ester are adopted as the raw materials to prepare high purity N-fatty acyl group amino acid, the raw materials are cheap, the equipment is simple, and waste water generated during the production process is less.

Palladium-catalyzed amidocarbonylation - A new, efficient synthesis of N-acyl amino acids

For the first time palladium catalysts have been used successfully for the amidocarbonylation reaction. The activity of the cobalt catalysts that were used exclusively beforehand has now been exceeded by an order of magnitude, and the reaction can be performed under far milder conditions. Palladium-catalyzed amidocarbonylation reactions can now be used for the synthesis of a much wider range of N-acyl amino acids.