13719-57-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-methoxybenzyl chloride is used as a synthetic intermediate for the development of various drugs and biologically active molecules. Its unique structure and reactivity allow for the creation of complex molecules with significant therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-CHLORO-4-METHOXYBENZYL CHLORIDE is employed as a key component in the synthesis of compounds that have agricultural applications, contributing to the development of effective pesticides and other agrochemical products.
Used in Fine Chemicals Production:
3-Chloro-4-methoxybenzyl chloride also serves as a synthetic intermediate in the production of fine chemicals for a range of industrial processes. Its role in these processes is essential for the synthesis of specialty chemicals that have specific uses in various industries.

Upstream product

• 50-00-0 formaldehyd 
• 766-51-8 2-Chloroanisole 
• 14503-45-8 3-chloro-4-methoxybenzyl alcohol 
• 4903-09-7 3-chloro-4-methoxy-benzaldehyde 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 7569-58-6 2-(3-chloro-4-methoxyphenyl)acetonitrile 
• 55614-53-4 6-(3-Chloro-4-methoxy-phenyl)-5-(4-chloro-phenyl)-2,2-dimethyl-hexan-3-one 
• 60736-66-5 3-chloro-4-(3'-chloro-4'-methoxybenzyloxy)-phenylacetic acid 
• 55614-55-6 6-(3-Chloro-4-methoxy-phenyl)-5-(3,4-dichloro-phenyl)-2,2-dimethyl-hexan-3-one 
• 98406-01-0 1-<1-<2-<(3-chloro-4-methoxybenzyl)oxy>phenyl>vinyl>-1H-imidazole 
• 7569-87-1 3-chloro-4-methoxyphenethylamine 
• 7569-90-6 (3-chloro-4-methoxy-phenethyl)-methyl-amine 
• 131567-11-8 (+/-)-7-chloro-8-hydroxy-3-methyl-1-(3'-bromophenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 131567-09-4 (+/-)-7-chloro-8-methoxy-1-(3'-bromophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 285978-30-5 1-(2-bromo-phenyl)-2-{[2-(3-chloro-4-methoxy-phenyl)-ethyl]-methyl-amino}-ethanol 
• 285978-33-8 1-(3-bromo-phenyl)-2-{[2-(3-chloro-4-methoxy-phenyl)-ethyl]-methyl-amino}-ethanol 
• 55614-54-5 4-(3-Chloro-4-methoxy-phenyl)-3-(4-chloro-phenyl)-butyric acid 
• 55614-56-7 4-(3-Chloro-4-methoxy-phenyl)-3-(3,4-dichloro-phenyl)-butyric acid 
• 55614-40-9 6-Chloro-3-(4-chloro-phenyl)-7-methoxy-1-methyl-naphthalene 

Relevant academic research and scientific papers

Preparation method of avanafil important intermediate

The invention provides a preparation method of an avanafil important intermediate. The target compound (3-chloro-4-methoxybenzylamine) is prepared according to a route shown as the specification. The preparation method provided by the invention has the advantages of cheap and easily available raw materials, short technical route, mild reaction conditions, low equipment requirement, and small health hazard to operators, and is in line with the idea of green chemistry. The method has high yield, and can obtain product with high purity, thus being suitable for industrial production.

PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

A compound of the formula wherein R1 is a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 nitrogen atom(s), which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle; X is an oxygen atom, a nitrogen atom optionally substituted by a hydrocarbon group having 1 to 5 carbon atom(s) or a sulfur atom optionally oxidized with 1 or 2 oxygen, Y is a bond or a C1-5 alkylene group, R2 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a C1-5 alkylthio group, (5) a carbocycle having 3 to 15 carbon atoms or (6) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s), provided that when Y is a bond, R2 is a carbocycle having 3 to 15 carbon atoms or a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s) and; one of R3 and R4 is a hydrogen atom or a group of the formula: -Z-R5 (Z is a bond or C1-10 alkylene group optionally having substituent(s) and R5 is (1) a hydrogen atom, (2) a hydroxy group, (3) a C1-5 alkoxy group, (4) a nitrile group, (5) a C1-5 alkoxy-carbonyl group, (6) a carboxyl group, (7) a carbamoyl group, (8) a (mono or di-C1-5 alkyl)carbamoyl group, (9) an amino group, (10) a (di or mono-C1-5 alkyl)amino group, (11) a (C1-5 alkoxy-carbonyl)amino group, (12) a C1-5 alkylthio group, (13) a carbocycle having 3 to 15 carbon atoms or (14) a heterocycle having a skeleton consisting of 3 to 15 atoms including 1 to 5 heteroatom(s)); the other is a group of the formula: -Z-R5 (Z and R5 are as defined above); and R3 and R4 may form, together with the adjacent nitrogen atom, a heterocycle having a skeleton consisting of 3 to 15 atoms, which heterocycle is attached by a secondary nitrogen atom constituting the heterocycle, wherein the above-mentioned heterocycle and a carbocycle having 3 to 15 carbon atoms are each optionally substituted by substituent(s) selected from the group consisting of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C7-16 aralkyl, C3-8 cycloalkyl, C3-8 cycloalkenyl, C6-14 aryl, C1-8 alkoxy, C1-3 alkylenedioxy, hydroxy, halogen atom, amino, (di or mono-C1-5 alkyl)amino, (C1-5 alkoxy-carbonyl)amino, (C1-5 acyl)amino, (C1-5 acyl) (C1-5 alkyl)amino, C1-5 alkylthio, nitrile, nitro, C1-5 alkoxy-carbonyl, carboxyl, C1-5 alkyl-carbonyloxy, oxo, thioxo, C1-6 acyl group, sulfamoyl and (di or mono-C1-5 alkyl)sulfamoyl, or a salt thereof or a prodrug thereof have a superior cGMP specific phosphodiesterase (PDE) inhibitory activity, and can be used as an agent for the prophylaxis or treatment of cardiovascular diseases such as angina pectoris, heart failure, cardiac infarction, hypertension, arteriosclerosis and the like, allergic diseases such as asthma, or disorders of male or female genital function and the like.