137333-34-7

Upstream product

• 100378-60-7 (+/-)-trans-tetrahydro-benzofuran-2,7-dione 
• 22274-75-5 1,3-diethyl 2-(3-oxocyclohexyl)propanedioate 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 108372-57-2 5,6-dihydro-3H,4H-benzofuran-2,7-dione 
• 64-17-5 ethanol 
• 597563-71-8 2-(3-oxo-4-propyl-cyclohexyl)-malonic acid diethyl ester 
• 930-68-7 cyclohexenone 

Downstream Products

• 66427-26-7 ethyl 2-(3-oxocyclohexyl)acetate 
• 1242435-78-4 2-(3-oxocyclohexyl)-N-[2-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]ethylsulfanyl]pyridin-3-yl]acetamide55 
• 137333-54-1 N-(2,2-Dimethoxy-ethyl)-2-[(2R,4R)-4-hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-acetamide 
• 137333-56-3 2-<2',2'-bis(methylthio)ethyl>-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-55-2 2-(2',2'-dimethoxyethyl)-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-62-1 2-(2'-hydroxyethyl)-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-57-4 2-<2',2'-bis(methylthio)ethyl>-2,3,4,5,6,7-hexahydro-1,5-methano-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-58-5 2-(formylmethyl)-2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-39-2 [9-(4-Methoxy-benzenesulfonyl)-4-oxo-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-acetic acid methyl ester 
• 137333-41-6 1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetamide 
• 137333-40-5 1,2,3,4-tetrahydro-4-oxo-9-<(p-methoxyphenyl)sulfonyl>carbazole-2-acetic acid 
• 137333-42-7 2-[(2R,4R)-4-Hydroxy-9-(4-methoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-2-yl]-acetamide 
• 137333-43-8 2,3,4,5,6,7-hexahydro-1,5-methano-3-oxo-7-<(p-methoxyphenyl)sulfonyl>-1H-azocino<4,3-b>indole 
• 137333-44-9 C₂₁H₂₂N₂O₃S 

Relevant academic research and scientific papers

Facile Synthesis of Spirocyclic Lactams from β-Keto Carboxylic Acids

A facile synthesis of spirocyclic lactams starting from β-keto carboxylic acids via a one-pot cascade reaction involving a Curtius rearrangement and an intramolecular nucleophilic addition of the enol carbon to the isocyanate intermediate is reported. The same conditions have also been used for the generation of fused cyclic lactams with similar good yields. The synthetic value of this method has been demonstrated by efficient synthesis of tetracyclic spirolactam 8 and pentacyclic spirolactam 9.

N-(3-amino-2-hydroxy-propyl) substd. alkylamidoalkanol compd.

Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

N-(3-amino-2-hydroxy-propyl)substituted alkylamide compounds

Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

Tetracyclic pyrrole lactam derivatives

Disclosed are the compounds of formula I STR1 wherein R and R1 -R3 independently represent hydrogen or lower alkyl, and m represents the integer 2 or 3; their methods of preparation; pharmaceutical compositions thereof, and their use