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Usage

Uses

Used in Biochemical Research:
Biotin-PEG3-(CH2)3-NH2 is used as a biotinylation agent for attaching biotin molecules to target molecules, such as proteins or nucleic acids, to facilitate their detection, purification, or immobilization. This is particularly useful in techniques like immunoassays, affinity chromatography, and in situ hybridization.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Biotin-PEG3-(CH2)3-NH2 is used as a functionalizing agent to enhance the solubility, stability, and bioavailability of drug molecules. By forming stable amide bonds with drug molecules, it can improve their pharmacokinetic properties and overall therapeutic efficacy.
Used in Diagnostic Applications:
Biotin-PEG3-(CH2)3-NH2 is used as a labeling agent in the development of diagnostic tools, such as immunoassays and biosensors. The stable amide bond formation allows for the attachment of biotin to specific target molecules, enabling their detection and quantification with high sensitivity and specificity.
Used in Cosmetics Industry:
In the cosmetics industry, Biotin-PEG3-(CH2)3-NH2 is used as a biotinylation agent to enhance the delivery and efficacy of active ingredients in skincare and hair care products. The formation of stable amide bonds with these ingredients can improve their penetration and absorption, leading to better results for consumers.
Used in Agricultural Applications:
Biotin-PEG3-(CH2)3-NH2 is used as a biotinylation agent in the development of biopesticides and biofertilizers. By attaching biotin molecules to active ingredients, it can improve their stability, uptake, and overall effectiveness in promoting plant growth and protecting crops from pests and diseases.

Upstream product

• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 35013-72-0 biotin N-Hydroxysuccinimide ester 
• 58-85-5 biotin 
• 142685-25-4 2,3,5,6-tetrafluorophenyl 2,2,2-trifluoroacetate 
• 173341-32-7 biotin 2,3,5,6-tetrafluorophenyl ester 
• 194920-63-3 tert-butyl (15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)carbamate 
• 120550-35-8 biotin pentafluorophenyl ester 
• 927888-44-6 3-(2-(2-(3-(trityl-amino)-propoxy)-ethoxy)-ethoxy)-propylamine 
• 58-85-5 5-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid 
• 58-85-5 5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid 
• 194920-62-2 tert-butyl N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate 
• 475114-55-7 C₂₂H₃₇F₃N₄O₆S 
• 452309-60-3 C₁₂H₂₃F₃N₂O₄ 

Downstream Products

• 1338951-00-0 C₃₅H₄₉N₉O₈S 
• 1431957-52-6 N-(15-oxo-19-((4S)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)-4-(6-(pyrimidin-2-yl)-1,2,4,5-tetrazin-3-yl)benzamide 
• 1620484-40-3 C₃₈H₅₄N₄O₁₂S 

Relevant academic research and scientific papers

Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces

(Chemical Equation Presented) Fixed to the spot: A new, efficient, and simple immobilization technique for the construction of chemical microarrays has been developed. This technique is applicable to the site-selective attachment of diverse substances, in

Quantitative detection of 8-oxo-7,8-dihydro-2′-deoxyguanosine using chemical tagging and qPCR

8-Oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) is a commonly formed DNA lesion that is useful as a biomarker for oxidative stress. Although methods for selective quantification of 8-oxodGuo exist, there is room for additional methods that are sensitive a

A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans

We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.

Biotinylated CdSe/ZnSe nanocrystals for specific fluorescent labeling

A set of two new surface ligands is presented for the preparation of water-soluble, biotinylated CdSe/ZnSe core/shell nanocrystals, suitable for fluorescent biological labeling. It consists of a thiolated diethyleneglycol derivative and an alkylthiol substituted biotin molecule, which replace the initial capping ligands at the nanocrystal surface. Successful ligand exchange and long-term photostability of the modified nanocrystals as well as their highly specific binding to neuronal cells are demonstrated in different labeling experiments.

Optimizing the selectivity of DIFO-based reagents for intracellular bioorthogonal applications

One of the most commonly employed bioorthogonal reactions with azides is copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC, a 'click' reaction). More recently, the strain-promoted azide-alkyne [3+2] cycloaddition (SPAAC, a copper-free 'click' reaction) was developed, in which an alkyne is sufficiently strained to promote rapid cycloaddition with an azide to form a stable triazole conjugate. In this report, we show that an internal alkyne in a strained ring system with two electron-withdrawing fluorine atoms adjacent to the carbon-carbon triple bond reacts to yield covalent adducts not only with azide moieties but also reacts with free sulfhydryl groups abundant in the cytosol. We have identified conditions that allow the enhanced reactivity to be tolerated when using such conformationally strained reagents to enhance reaction rates and selectivity for bioorthogonal applications such as O-GlcNAc detection. Published by Elsevier Ltd.

Changshanone derivatives and their pharmaceutical compositions and uses

The present application relates to a changshanone derivative and a pharmaceutical composition and use thereof, the changshanone derivative is shown in formula I, wherein m is 1 to 4, n is 1 to 10, A is H or a detection marker, such as a biotin marker. The present application further relates to a pharmaceutical composition comprising a derivative of changshanone of formula I and its application in the treatment of cancer. Equation I.

Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition

A facile and convergent procedure for the synthesis of azobenzene-based probe was reported, which could selectively release interested proteins conducted with sodium dithionite. Besides, the cleavage efficiency is closely associated with the structural features, in which an ortho-hydroxyl substituent is necessary for reactivity. In addition, the azobenzene tag applied in the Ac4GlcNAz-labled proteins demonstrated high efficiency and selectivity in comparison with Biotin-PEG4-Alkyne, which provides a useful platform for enrichment of any desired bioorthogonal proteomics.

(1H-imidazo [4, 5-b] pyridine-6-yl) pyridine derivative and application thereof

The invention discloses a (1H-imidazo [4, 5-b] pyridine-6-yl) pyridine derivative and a preparation method thereof. The method is characterized in that: the (1H-imidazo [4, 5-b] pyridine-6-yl) pyridine derivative of which the structural formula is disclosed by the invention has obvious anti-cancer activity; in-vitro cytotoxicity experiments show that the (1H-imidazo [4, 5-b] pyridine-6-yl) pyridine derivative generally has very good cytotoxic activity on various cancer cells such as MCF7, HepG2 and A549, and is an EGFR and CDK9 small molecular ligand for targeted inhibition of RAR.

From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1)

Protein-protein interactions (PPIs) have emerged as significant targets for therapeutic development, owing to their critical nature in diverse biological processes. An ideal PPI-based target is the protein myeloid cell leukemia 1 (MCL1), a critical prosurvival factor in cancers such as multiple myeloma where MCL1 levels directly correlate to disease progression. Current strategies for halting the antiapoptotic properties of MCL1 revolve around inhibiting its sequestration of proapoptotic factors. Existing inhibitors disrupt endogenous regulatory proteins; however, this strategy actually leads to an increase of MCL1 protein levels. Here, we show the development of hetero-bifunctional small molecules capable of selectively targeting MCL1 using a proteolysis targeting chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon ubiquitination pathway, making these PROTACs a first step toward a new class of antiapoptotic B-cell lymphoma 2 family protein degraders.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

Compounds of formula (I') and methods of their use and preparation, as well as compositions comprising compounds of formula (I').