137473-27-9

Basic information

• Product Name: 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-
• CAS NO: 137473-27-9
• Molecular Formula: C12H14O4S
• Molecular Weight: 254.307
• Mol File: 137473-27-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-(137473-27-9)
• EPA Substance Registry System: 2-Propenoic acid, 3-[4-(methylsulfonyl)phenyl]-, ethyl ester, (E)-(137473-27-9)

Safety Data

• Hazardous Substances Data: 137473-27-9(Hazardous Substances Data)

Upstream product

• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 64-17-5 ethanol 
• 5345-30-2 3-(4-methanesulfonyl-phenyl)-acrylic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 100515-19-3 1-(1,1-dimethoxy-methyl)-4-methanesulfonyl-benzene 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 100515-17-1 1-(1,1-dimethoxy-methyl)-4-methylsulfanyl-benzene 
• 97410-25-8 1-(methylsulfonyl)-4-vinyl-benzene 
• 4114-31-2 ethylhydrazine carboxylate 
• 197905-49-0 4‐methoxy‐N‐(4‐(methylsulfonyl)benzylidene)aniline 
• 24045-02-1 (benzothiazole-2-sulfonyl)-acetic acid ethyl ester 

Downstream Products

• 5345-30-2 3-(4-methanesulfonyl-phenyl)-acrylic acid 
• 1373543-38-4 ethyl (2R,3S)-2,3-dihydroxy-3-[4-(methylsulfonyl)phenyl]propanoate 
• 1373543-40-8 ethyl (2R,3S)-3-hydroxy-3-[4-(methylsulfonyl)phenyl]-2-{[(4-nitrophenyl)sulfonyl]oxy}propanoate 
• 41917-86-6 trans-4-(methylsulfonyl)cinnamaldehyde 
• 125872-64-2 (E)-3-[4-(methylsulfonyl)phenyl]prop-2-en-1-ol 

Relevant articles and documents

Oxidative alkoxycarbonylation of terminal alkenes with carbazates

A range of terminal alkenes smoothly underwent palladium-catalyzed oxidative alkoxycarbonylation with carbazates under an oxygen atmosphere to afford structurally diverse α,β-unsaturated esters in moderate to good yields with excellent regioselectivity and E selectivity.

An efficient enantioselective synthesis of florfenicol based on sharpless asymmetric dihydroxylation

An efficient and highly enantioselective synthesis of florfenicol- via a new intermediate threo-dihydroxy ester, with a Sharpless asymmetric dihydroxylation as the key step, is reported. A ring-opening/reduction strategy avoids the formation of a chlorinated byproduct that occurs in Schumachers phenyloxazoline procedure. The overall yield of florfenicol by this new process is 23% based on 4-(methylsulfonyl)benzaldehyde. Georg Thieme Verlag Stuttgart · New York.

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.