1379337-67-3

Upstream product

• 606-45-1 2-methoxybenzoic acid methyl ester 
• 1146214-77-8 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester 
• 141-53-7 sodium formate 
• 146014-66-6 methyl 2-fluoro-6-iodobenzoate 
• 111771-08-5 2-fluoro-6-iodobenzoic acid 

Downstream Products

• 1360789-53-2 methyl 2-hydroxy-6-iodobenzoate 
• 1360789-54-3 methyl 2-hydroxy-6-((E)-hept-1-enyl)benzoate 
• 1360789-55-4 methyl 2-hydroxy-6-((E)-prop-1-enyl)benzoate 
• 1360789-38-3 methyl 2-acetoxy-6-((E)-prop-1-enyl)benzoate 
• 1360789-37-2 methyl 2-acetoxy-6-((E)-hept-1-enyl)benzoate 
• 1360789-66-7 (R)-methyl 2-acetoxy-6-((E)-4-hydroxyhept-1-enyl)benzoate 
• 1360789-64-5 (R)-methyl 2-acetoxy-6-((E)-4-( tert-butyldimethylsilyloxy)hept-1-enyl)benzoate 
• 1360789-65-6 C₂₁H₃₄O₄Si 
• 32885-83-9 (3S,4S)-4-hydroxymellein 

Relevant academic research and scientific papers

N,B-bidentate boryl ligand-supported iridium catalyst for efficient functional-group-directed C-H borylation

Convenient silylborane precursors for introducing N,B-bidentate boryl ligands onto transition metals were designed, prepared, and employed in ready formation of irdium(IIl) complexes via Si-B oxidative addition. A practical, efficient catalytic ortho-borylation reaction of arenes with a broad range of directing groups was developed using an in situ generated catalyst from the silylborane preligand 3c and [IrCl(COD)]2.

Synthesis and antibacterial activity of racemic paecilocin A and its derivatives against methicillin-sensitive and -resistant Staphylococcus aureus

A total synthesis in four steps of racemic paecilocin A, a natural marine phthalide is reported. The synthetic pathway includes an iodine-magnesium exchange followed by a condensation on an aldehyde and represents a sufficiently flexible approach to allow the synthesis of twelve analogs. The synthesized compounds were investigated for their antibacterial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant strain (MRSA). Three analogs were found to have similar or better antibacterial activity than the natural compound on MRSA.