169879-06-5 Usage
Uses
Used in Medicinal Chemistry Research:
4-bromo-1-(4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with bromo and nitrobenzoyl substitutions may offer specific binding affinities or interactions with biological targets, making it a valuable tool in the development of new drugs.
Used in Drug Design and Development:
In the pharmaceutical industry, 4-bromo-1-(4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one is used as a lead compound for drug design. Its structural features can be further modified to optimize its pharmacological properties, such as potency, selectivity, and safety, which is crucial for the creation of effective therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 169879-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,9,8,7 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 169879-06:
(8*1)+(7*6)+(6*9)+(5*8)+(4*7)+(3*9)+(2*0)+(1*6)=205
205 % 10 = 5
So 169879-06-5 is a valid CAS Registry Number.
169879-06-5Relevant academic research and scientific papers
Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1] benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: An Arginine Vasopressin Antagonist
Tsunoda, Takashi,Yamazaki, Atsuki,Iwamoto, Hidenori,Sakamoto, Shuichi
, p. 883 - 887 (2013/09/05)
A novel, reliable, and cost-effective synthetic route to N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl] -phenyl}biphenyl-2-carboxamide monohydrochloride (1, YM087), a potent Arginine vasopressin antagonist, has been developed. Using moisture-controlled potassium carbonate, imidazole formation from α-bromoketone furnished imidazobenzazepine, avoiding potential oxazole-ring formation. Catalytic reduction of nitro imidazobenzazepine afforded the corresponding amine in high yields. Treatment of the imidazole-containing amine directly, with a carbonyl chloride, afforded the target amide circumventing protection of the imidazole.
